Research Associate II

Worcester, Worcester County
May 13, 2014



The Department of Pathology is composed of three divisions:  Basic ScienceAnatomic Pathology and Clinical Pathology. All of these are strong and growing. All of the Divisions participate in and contribute to the multiple missions of the Department including research, clinical care, and teaching.

Research in the Department is focused in two major areas. One of these areas is Immunobiology and Immunopathology. This effort is centered in the Basic Science Division and is internationally recognized. The second area is in the development of diagnostics for human disease. This effort is centered in the Divisions of Anatomic Pathology and Clinical Pathology and has been highly successful in the development.


The research in this laboratory is aimed at understanding the signal transduction pathways importantforTlymphocyte development and activation. For these studies, we use a combination of mouse genetics (transgenics and knockouts), biochemistry, and cellular immunology. Our current work focuses on three projects. First, we have identified a tyrosine kinase, Jak3, involved in cytokine receptor signaling, and have generated Jak3-deficient mice. These mice have severe defects in lymphocyte development and function. Second, we have identified a novel tyrosine kinase, Itk, involved in T cell receptor signaling. Using Itk-deficient mice generated in the lab we are currently examining the role of this protein in lymphocyte development and activation.


Under the general direction of the Principal Investigator or designee, the Research Associate II performs a variety of complex research experiments and is responsible for overseeing laboratory operations within the Department.


  • Perform complex laboratory experiments and conduct in-depth analysis of research experiments
  • Write standard operating procedures, schedule work, analyze data, maintain accurate records, and write reports
  • Report the status of projects and observations to the Department Chair
  • Ensure departmental computer resources remain functional and provide on-site support to Investigators as requested
  • Design and execute protocols and experiments, modify protocols as needed, and may be responsible for own research project
  • Manage laboratory research staff
  • Responsible for overall laboratory organization including oversight of safety protocols and the maintenance of related records 
  • May assist with budget and/or operational aspects of grant and contract proposals
  • Long-range planning for laboratory and departmental equipment maintenance and replacement. Assist in procurement of departmental equipment. Responsible for physical inventory of all equipment, and maintaining records of all equipment acquired, moved off-site, or discarded
  • Oversee and coordinate the use of centralized departmental facilities
  • Work with Facilities Engineering, Environmental Health and Safety, and Radiation Safety to ensure department facilities and laboratories are in compliance with federal, state and institutional regulations
  • Assist in writing the text of scientific publications and grants.  Review literature
  • Oversee and assist in the training of new laboratory personnel, students, and collaborators
  • Comply with all safety and infection control standards
  • Perform other duties as required.




  • Bachelor’s degree in the Biological Sciences, or equivalent experience
  • 5 years of relevant research experience.
  • Knowledge of Microsoft Office products.
  • Strong ability to analyze complex visual data in a quantitative and objective manner.
  • Judgment and action skills required to solve commonly encountered problems


Under the direction of the Principal Investigator, or designee



Supervise aides, technicians, and associates



Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.


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