Postdoctoral Researcher – Immunology / Oral Biology

The Ko Laboratory at the University of Pennsylvania School of Dental Medicine is seeking a highly motivated postdoctoral fellow to join an NIH-funded research program investigating host–microbe interactions at the oral epithelial barrier.

Our research uses periodontitis as a model to understand how excess iron resulting from chronic inflammation alters epithelial and stromal cell function, promotes inflammatory cell death, and drives tissue destruction. We integrate genetically engineered mouse models, clinically derived human tissues, immunology, spatial and single-cell molecular profiling, and computational biology to uncover mechanisms linking iron-dependent cell death with chronic inflammatory disease. The successful candidate will have the opportunity to work in a collaborative, multidisciplinary environment at Penn Dental Medicine's Levy Building and interact with investigators across Penn's vibrant biomedical research community.

What We Offer

• Training in cutting-edge approaches including human tissue biology, immunology, and spatial/single-cell technologies
• Opportunities to develop interdisciplinary collaborations across the University of Pennsylvania
• Mentorship focused on scientific independence, grant writing, career development, and publication
• A collaborative and supportive research environment

Required Qualifications

• Ph.D., D.M.D./Ph.D., M.D./Ph.D., or equivalent degree in Immunology, Oral Biology, Cell Biology, Molecular Biology, or a related field
• Demonstrated ability to independently design, execute, and interpret scientific experiments
• Strong written and verbal communication skills
• Ability to work both independently and collaboratively in a multidisciplinary research environment

Preferred Qualifications

• Experience with murine models of disease
• Experience with cell culture and in vitro immunological assays
• Surgical or microdissection experience
• Experience with computational biology or bioinformatics (R, Python, or related platforms)
• Track record of peer-reviewed publications

What We Offer

• Training in cutting-edge approaches including human tissue biology, immunology, and spatial/single-cell technologies
• Opportunities to develop interdisciplinary collaborations across the University of Pennsylvania
• Mentorship focused on scientific independence, grant writing, career development, and publication
• A collaborative and supportive research environment

Interested applicants should submit:

1. A curriculum vitae (CV)
2. A cover letter describing previous research experience, scientific interests, and long-term career goals
3. Contact information for three professional references

Applications will be reviewed on a rolling basis until the position is filled.

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.