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Pediatric Hematology Oncology - Project Scientist -Jonas Lab

Employer
University of California, Los Angeles
Location
Los Angeles

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Administrative Jobs
Academic Affairs, Research Staff & Technicians
Employment Type
Full Time
Institution Type
Four-Year Institution

Job Details



Pediatric Hematology Oncology - Project Scientist -Jonas Lab
University of California Los Angeles



Requisition Number: JPF09392


The Jonas Lab in the Department of Pediatrics, David Geffen School of Medicine & California NanoSystems Institute at UCLA is seeking a highly motivated project scientist interested in pursuing interdisciplinary research at the interface of nanoscience and regenerative medicine. We have a multidisciplinary research team interested in developing new nanotechnology-enabled methods to support the childhood cancer and regenerative medicine research communities in accelerating the discovery and implementation of gene and cellular therapeutic approaches and precision-medicine-based diagnostic strategies.

With support from the NIH's High-Risk High-Reward Program, our group leverages advances in microfluidics, nanofabrication, and gene editing approaches to explore the ultimate limits of miniaturization. These capabilities empower our efforts to create tools that enable stem cell biologists to probe and to interact with stem cells more precisely and empower clinical scientists to apply this knowledge to design and implement new therapies more rapidly and broadly.

We have multiple postdoctoral positions available immediately to:
  • Establish rapid, safe, cost-effective, and efficient intracellular delivery methods for genes and genome-editing machinery. The goal of this NIH-funded project is to establish new manufacturing platforms for gene and stem cell-based therapies directed at pediatric cancers, hematologic disorders, primary immunodeficiencies, and other genetic diseases.
  • Design and apply nanocarrier systems to enable cystic fibrosis gene therapies.
  • Develop microfluidic liquid biopsy technologies for monitoring treatment response to pediatric sarcomas and other childhood malignancies
  • Apply rapid prototyping approaches to fabricate three-dimensionally printed tools for organoid development & toxicity screening of electronic cigarette/vaping products

Qualifications:
  • PhD, MD/PhD, or equivalent in Bioengineering, Materials Science, Chemistry, Mechanical Engineering, Physics, Electrical Engineering, Molecular Biology or related life science fields of study
  • Background in nanoparticle synthesis & characterization and mRNA therapeutics
  • Solid understanding and experience in micro/nanofabrication techniques, microfluidic devices, three-dimensional printing, device design and characterization
  • Experience in cell culture, cell biology & molecular biology, immunofluorescence/flow cytometry, next generation sequencing techniques, gene editing methods, and biochemical techniques desired
  • Ability to multitask and quickly adapt to new research challenges
  • Excellent communication skills and ability to work in a diverse, interdisciplinary research environment and to interact with computational and experimental scientists
  • Ability to function independently in the laboratory and lead project teams
  • Desire to engage and mentor graduate, medical, and undergraduate students across different academic disciplines

    Skills:
  • Experience with micro/nanofabrication techniques, including photolithography and three-dimensional printing for rapid prototyping and application of microfluidic systems
  • Experience in the design of computer models/simulations for prototyping of project-specific devices
  • Experience in nanoparticle synthesis and characterization (e.g., lipid nanoparticles, polymeric, plasmonic nanomaterials)
  • Experience with cell culture, transfection, immunofluorescence/flow cytometry, and biochemical and molecular biology techniques
  • Comfortable working with human primary cell types including hematopoietic stem cells, immune cells, or pluripotent stem cells.
  • Experience in the development and characterization of gene editing reagents, PCR, cloning, and/or Next-Generation sequencing desired
  • Working knowledge of laboratory notebook management and data management
  • Knowledge of aseptic and laboratory technique
  • Meticulous organizational and data analysis skills

    Duties and Responsibilities:
  • Ability to work and lead more independently and multitask projects more extensively
  • Leadership and coordination of project activities and collaborative efforts. The candidate will report directly to the PI
  • Oversee development of technology platforms for cellular therapy manufacturing, nanoparticle vehicles, organoids, and/or liquid biopsy diagnostic tests and characterization of cell products resulting from this work
  • Ability to multitask and contribute to and oversee multiple collaborative projects efficiently and effectively
  • Supervision, mentorship, and teaching of undergraduate, graduate, and medical students, new postdoctoral trainees, and staff research associates in the lab
  • Required to communicate well with other scientists, regulatory personnel, biotech companies, sponsored research organizations, and other scientific personnel worldwide.
  • Supervise preparation of manuscripts for publication of results of independent and collaborative laboratory research. The candidate will also provide support in publishing the results of various projects.
  • Participate in laboratory meetings, educational sessions, general and specific safety training and other training sessions
  • Assist and work with PI directly to identify new opportunities and research directions for the laboratory
  • Assist PI in preparation of grant proposals and progress reports, as needed.
  • Desire to work toward transitioning to independence as an early-stage scientific investigator
  • Performs other duties and laboratory responsibilities as requested.

    Interested candidates can apply online at https://recruit.apo.ucla.edu/JPF09392

    Cultural North Star
    The shared values of the DGSOM are expressed in the Cultural North Star, which was developed by members of our community and affirms our unswerving commitment to doing what's right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. Please read more about this important DGSOM program at https://medschool.ucla.edu/cultural-north-star.

    Anti-Racism Roadmap
    The David Geffen School of Medicine Anti-racism roadmap is our co-created path to ensuring racial justice, equity, diversity and inclusion. We are committed to actively dismantling structural racism in our organization as described in more detail at: https://medschool.ucla.edu/diversity-anti-racism-roadmap.


    To apply, please visit: https://recruit.apo.ucla.edu/JPF09392


    The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy, see: UC Nondiscrimination & Affirmative Action Policy, https://policy.ucop.edu/doc/4000376/DiscHarassAffirmAction


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  • Organization

    Working at University of California, Los Angeles

    UCLA is a public research university located in the Westwood neighborhood of Los Angeles, California. It was founded in 1919 and is the second oldest of the ten campuses affiliated with the University of California system. UCLA offers over 300 undergraduate and graduate degree programs in a wide range of disciplines and enrolls about 26,000 undergraduate and about 12,000 graduate students from the United States and around the world every year.

    UCLA features the College of Letters and Science, seven general campus professional schools, and four professional schools for the health sciences. The UCLA College of Letters and Science has 34 academic departments and 900 faculty, and houses the majority of UCLA's 129 undergraduate majors as well as the students in the Graduate Division of Letters and Sciences. The UCLA College Honors Program is also housed in the College. The College of Letters and Science's programs are divided into five academic divisions: humanities, social sciences, life sciences, physical sciences, and the International Institute. UCLA also offers certificate programs, undergraduate degree-credit and continuing education credits for non-full-time students through its UCLA Extension education program.

    The 2010 edition of U.S. News & World Report ranked UCLA as the 24th best university in the nation and 32nd best in the world. In the 2007 edition of U.S. News and World Report, UCLA Medical Center was ranked best in the West, as well as one of the top 3 hospitals in the United States alongside Mayo Clinic, Cleveland Clinic, Massachusetts General Hospital, and Johns Hopkins Hospital. In 15 of the 16 medical specialty areas examined, UCLA Medical Center ranked in the top 20.

    The campus' location in Los Angeles makes excursions to local museums, theaters, or other entertainment venues relatively quick and easy.

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