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Postdoctoral Fellow Retina Biochemistry and Clinical Disease Modeling Laboratory

Employer
University of California, Los Angeles
Location
Los Angeles
Salary
$

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Faculty Jobs
Science & Technology, Life Sciences
Position Type
Postdoc
Employment Type
Full Time
Institution Type
Four-Year Institution

Job Details



Postdoctoral Fellow - Retina Biochemistry & Clinical Disease Modeling Laboratory

The UCLA Stein Eye Institute and Department of Ophthalmology invite applications for postdoctoral scholars to work on basic science and translational research projects in The Retina Biochemistry & Clinical Disease Modeling Laboratory. Radu group focuses on studying the retinal pigment epithelium (RPE) in normal and pathological status pertinent to Stargardt disease and age-related macular degeneration.

Research: Current studies are directed towards understanding the intercellular organelle dynamics in the RPE centered on lysosomes maturation, recycling of retinoids and lipids relevant to cell bioenergetics (mitochondria), and identification of complement-mediated signaling pathways in aging and disease status. Projects will include in vivo studies utilizing novel mouse models and in vitro biochemical and electrophysiological approaches to investigate disease pathology in a “disease-in-a-dish” model. Experiments will involve cutting-edge cell and molecular biology techniques including differentiation of iPSCs and iPSC-derived RPE cells, spatial transcriptomes/ multiomics analysis, andadvanced microscopy imaging tools.

Qualifications: The position is for a highly motivated PhD, MD, or MD/PhD who aims to develop an independent research career. The postdoctoral fellow will lead research projects, execute experiments and analyze data, write manuscripts and present at scientific meetings.

Requirements
  • Knowledge of and experience with mouse genetics, cell and molecular biology, and basic biochemistry techniques are required for this position.
  • A strong background in stem cell biology, in vitrodifferentiation of iPSCs, and RNASeq/single cell transcriptome analysis are preferred. Experience in confocal microscopy, advanced molecular biology, genomic data analysis, and mammalian cell culture are highly desirable. Specific training in retinoids biochemistry related to visual processes will be offered during the fellowship.
  • Candidates must possess strong communication skills, ability to work independently and in a team setting, display self-initiative and attention to detail, enthusiasm to explore new techniques and concepts, and adherence to highest ethical principles while working with laboratory animals.
  • Individualized mentorship is tailored to their personal career and publications goals. Successful candidate will participate in weekly lab meetings, seminar series (both our Institute and UCLA), as well as national and international specialized conferences. Regular meetings with the PI will reassure common scientific expectations are met, and skill-building and advance knowledge in the field are achieved.

    Apply: Interested applicants should email an updated CV, complete contact information for 3 references, cover letter describing published and ongoing work, and a statement of future research interest (1-2 pages) to: Roxana Radu (radu@jsei.ucla.edu).

    - The Cultural North Star was developed by members of our community and affirms our unswerving commitment to doing what's right, making things better, and being kind. These are the standards to which we hold ourselves, and one another. https://medschool.ucla.edu/cultural-north-star

    - The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. UCLA has programs to assist in partner employment, childcare, schooling and other family concerns.





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  • Organization

    Working at University of California, Los Angeles

    UCLA is a public research university located in the Westwood neighborhood of Los Angeles, California. It was founded in 1919 and is the second oldest of the ten campuses affiliated with the University of California system. UCLA offers over 300 undergraduate and graduate degree programs in a wide range of disciplines and enrolls about 26,000 undergraduate and about 12,000 graduate students from the United States and around the world every year.

    UCLA features the College of Letters and Science, seven general campus professional schools, and four professional schools for the health sciences. The UCLA College of Letters and Science has 34 academic departments and 900 faculty, and houses the majority of UCLA's 129 undergraduate majors as well as the students in the Graduate Division of Letters and Sciences. The UCLA College Honors Program is also housed in the College. The College of Letters and Science's programs are divided into five academic divisions: humanities, social sciences, life sciences, physical sciences, and the International Institute. UCLA also offers certificate programs, undergraduate degree-credit and continuing education credits for non-full-time students through its UCLA Extension education program.

    The 2010 edition of U.S. News & World Report ranked UCLA as the 24th best university in the nation and 32nd best in the world. In the 2007 edition of U.S. News and World Report, UCLA Medical Center was ranked best in the West, as well as one of the top 3 hospitals in the United States alongside Mayo Clinic, Cleveland Clinic, Massachusetts General Hospital, and Johns Hopkins Hospital. In 15 of the 16 medical specialty areas examined, UCLA Medical Center ranked in the top 20.

    The campus' location in Los Angeles makes excursions to local museums, theaters, or other entertainment venues relatively quick and easy.

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