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Post Doctoral Scholar

Employer
The Ohio State University
Location
Columbus Campus

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Administrative Jobs
Institutional & Business Affairs, Auxiliary Services
Position Type
Postdoc
Employment Type
Full Time
Institution Type
Four-Year Institution

Job Details

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Job Title:Post Doctoral Scholar

Department:Veterinary Medicine | Veterinary Biosciences

Dr. Gaofeng Xiong’s laboratory in the Department of Veterinary Biosciences at The Ohio State University is seeking a motivated candidate for a postdoctoral position.

Dr. Xiong’s research primarily focuses on understanding important molecular mechanisms and biology underlying breast cancer progression, metastasis, therapy resistance and recurrence, as well as identifying novel potential biomarkers and therapeutic targets for breast cancer treatment (Proc Natl Acad Sci U S A 2020 & 2023, Nature Communications 2018, J Biol Chem 2022, Cancer Research 2015 & 2012, ACS Nano 2015, Integrative Biology 2015, Molecular and Cellular Biology 2014). To learn more about this lab's research, please visit the below link:

Gaofeng Xiong | College of Veterinary Medicine (osu.edu)

A Post Doctoral Scholar will be involved in the project investigating the role of P4HA1 in endocrine resistance of breast cancer, which is recently awarded by external funding from NIH-NIA. Resistance to endocrine therapy and recurrence are the leading causes of mortality in breast cancer patients. P4HA1, the alpha subunit of Prolyl hydroxylation (P4H), is an enzyme hydroxylates proline into 4-hydroxyproline of collagens and other proteins with the -X-Pro-Gly- sequences as collagens in the endoplasmic reticulum. This project will focus on the uncanonical role of P4HA1 as a key player coordinates the crosstalk between endocrine resistance and cellular stresses (oxidative stress, endoplasmic reticulum stress), and explore P4HA1 as a novel therapeutic target for endocrine resistant luminal breast cancer. In vitro 2D/3D tissue culture model, in vivo breast cancer cell line and patient-derived xenograft models, as well as conditional knock out mouse model will be used in this project.

How to Apply:

Applications should include a CV, representative publications, contact information of references, and a cover letter detailing how your research experiences match this position. Review of applicants will begin immediately and will continue until the position is filled.

Minimum Education Required

Ph.D. in Biology, molecular, or other cell biology-related fields

Essential Qualifications

The candidate will be expected to conduct standard molecular and cellular experiments like PCR, western blots, IHC, IF, FACS, tissue culture, etc.

Desired Qualifications

Xenograft model and transgenic mouse model experiences are desired but not required. Strong writing, analytical, and communication skills are expected.

Additional Information:

The Ohio State University is a public institution that was founded in 1870. The Ohio State University's ranking in the 2024 edition of Best Colleges is National Universities, #43. The Ohio State University College of Veterinary Medicine has been a top-five program in the U.S. News & World Report rankings for the past decade and was ranked third among U.S. veterinary colleges and sixth in the world in the 2020 QS rankings. The Ohio State University Comprehensive Cancer Center – James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation’s largest public universities.

Additional Information:

This is a term position.

Location:Veterinary Medicine Academic (0136)

Position Type:Term (Fixed Term)

Scheduled Hours:40

Shift:First Shift

Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.

Thank you for your interest in positions at The Ohio State University and Wexner Medical Center. Once you have applied, the most updated information on the status of your application can be found by visiting the Candidate Home section of this site. Please view your submitted applications by logging in and reviewing your status. For answers to additional questions please review the frequently asked questions.

The Ohio State University is an equal opportunity employer.

All qualified applicants will receive consideration for employment without regard to age, ancestry, color, disability, ethnicity, gender identity or expression, genetic information, HIV/AIDS status, military status, national origin, race, religion, sex, gender, sexual orientation, pregnancy, protected veteran status, or any other basis under the law.

Applicants are encouraged to complete and submit the Equal Employment Identification form.

Organization

About The Ohio State University

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Ohio State is regularly honored as one of the nation’s top 20 public universities. With campuses and research centers throughout the state, the institution’s unrivaled depth and breadth advance innovation, health care and research within Ohio’s communities. For more than 150 years, Ohio State has inspired the next generation of leaders, discovering groundbreaking medical breakthroughs and finding solutions to the problems the world is facing now.

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Explore our Extensive Benefits

Ohio State provides access to opportunities and resources for all employees. Starting your first day, Ohio State offers you a comprehensive benefits package.

· WORK-LIFE: Flexible and remote work arrangements where applicable, child care program, and access to educational, athletic and cultural events.

· RETIREMENT: State pension and alternative options with competitive employer contributions, as well as optional supplemental plans.

· HEALTH: Medical, dental, vision and prescription coverage, life insurance, flexible spending accounts and wellness programming.

· TIME OFF: Paid vacation and sick time, parental and medical leave plus 11 paid holidays. Short and long-term disability options also available.

· FINANCIAL: Tuition assistance for employees and their dependents, adoption assistance, and discounts with preferred vendors and university partners.

· WELLNESS: Lifestyle spending account, employee assistance program, health reimbursement account, and employee wellness program.

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