Postdoctoral Fellow, Laboratory of Dr. Kuo-Fen Lee

Salk Institute for Biological Studies
La Jolla, CA

Job Details

The Lee Group are looking for several postdoctoral candidates to understand the logic of aging and brain disease across multiple species and models, e.g., Alzheimer’s Disease (AD), Parkinson Disease (PD) and Schizophrenia (SCZ). We apply an integrative and whole brain network (e.g., graph theory), multi-scale and multiple-modal approach that includes single neurons-barcoding for BRICseq, multiomic single nuclei (sn)-RNAseq and sn-ATACseq, spatial transcriptomics and proteinomics, circuit mapping, in vivo physiological recording, optogenetics, large-scale unbiased behavioral screen, stem cells and gene-editing in embryos. Here are examples of research areas.

The logic of prodromal AD: AD is a progressive neu­rodegenerative disorder as a result of a complex series of events that take place in the brain over a long period of time—the prodromal phase can last longer than 20 years in humans—before being clinically diagnosed as AD dementia. The goal of this project is to elucidate the logic of where and how AD is initiated and progresses from prodromal phase to AD dementia. We will use AI with these multi-scale and multi-modal big datasets as well as public datasets to decipher the logic of prodromal AD.

Neural circuits and molecular mechanisms of PD and SCZ: PD is characterized by a prodromal phase with selectively cell vulnerability. e.g., dopamine neurons, resulting in both motor and non-motor symptoms, e.g., SCZ-like and cognitive impairments. We will apply multi-scale and multi-modal approach to elucidate cell-specific circuits, including those mediated by neuromodulators (e.g., dopamine, acetylcholine and norepinephrine) in basal ganglia and basal forebrain, and molecular mechanisms controlling motor (e.g., resting tremor) and non-motor symptoms.

Modeling human development and brain disease and regenerative medicine in non-rodent species: To bridge the gap between mice and human in both basic and translation science, we have been developing blastomere-like stem cells and genetic tools in non-rodent species to uncover the functions of gene and neural circuits underlying embryonic development (e.g., totipotency), brain disease and regenerative medicine.

The ideal candidates will be biologists who have training in neurobiology and disease and whole brain network (e.g., graph theory), multi-scale and multiple-modal approach mentioned above. They should be intellectually curious, highly productive, driven to uncover new and impactful biology and to apply this knowledge to the larger problem of brain function and disease and regenerative medicine, and enjoy working in a committed and diverse team.

Ph.D. in neurobiology and disease or related fields.

The expected pay range for this position is $65,000-$71,000 per annum.
Salk Institute provides pay ranges representing its good faith estimate of what the institute reasonably expects to pay for a position. The pay offered to a selected candidate will be determined based on factors such as (but not limited to) the scope and responsibilities of the position, the qualifications of the selected candidate, departmental budget availability, internal equity, geographic location, and external market pay for comparable jobs.

Application Instructions:

Applicants should submit a current resume, a list of their pre-prints and publications, names of three references, and an indication of how their expertise and academic accomplishments make them a good fit for the position.



Working at Salk Institute for Biological Studies

The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused on both discovery and mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes, and cardiovascular disorders by studying neuroscience, genetics, cell and plant biology, and related disciplines.

Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.

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