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Post-Doctoral Fellow

Employer
University of Colorado Anschutz Medical Campus
Location
Aurora

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Faculty Jobs
Health & Medical, Medicine
Administrative Jobs
Institutional & Business Affairs, Auxiliary Services
Position Type
Postdoc
Employment Type
Full Time
Institution Type
Four-Year Institution
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Post-Doctoral Fellow - 27283 Faculty

Description
University of Colorado | CU Anschutz Medical Campus

Division of Rheumatology

Post Doctoral Fellow

Position #00801086 – Requisition #27283



* Applications are accepted electronically ONLY at www.cu.edu/cu-careers

The University of Colorado has a requirement for COVID-19 vaccinations and full completion thereof by 9/1/21 or upon start date. Information regarding this requirement, and exemptions can be found at:

Anschutz: https://www.ucdenver.edu/docs/librariesprovider284/default-document-library/3000-general-admission/3012---covid-19-vaccination-requirement-and-compliance.pdf?sfvrsn=4e9df3ba_2

Denver: https://www.ucdenver.edu/coronavirus

Exemptions vary by campus location/department.

Campus/Unit-Specific Exemptions:
    Anschutz Campus – Exemptions are allowed for medical or religious reasons. Denver Campus - Exemptions are allowed for medical, religious, or personal reasons. Consolidated/Central Services Administration – Will follow Anschutz policy on exemptions.

The University of Colorado Anschutz Medical Campus seeks individuals with demonstrated commitment to creating an inclusive learning and working environment. We value the ability to engage effectively with students, faculty and staff of diverse backgrounds.

The Division of Rheumatology has an opening for a full-time Post Doctoral Fellow position.

The University of Colorado Anschutz Medical Campus is a world-class medical destination at the forefront of transformative science, medicine, education and patient care. The campus encompasses the University of Colorado health professional schools, more than 60 centers and institutes, and two nationally ranked independent hospitals - UCHealth University of Colorado Hospital and Children's Hospital Colorado - that treat more than two million adult and pediatric patients each year. Innovative, interconnected and highly collaborative, the University of Colorado Anschutz Medical Campus delivers life-changing treatments, patient care and professional training and conducts world-renowned research fueled by over $650 million in research grants. For more information, visit www.cuanschutz.edu.

Overall Description of Responsibility or Nature of Work

This position reports directly to Dr. Kristen Demoruelle in the Division of Rheumatology. Dr. Demoruelle's research program investigates the immunobiology of the lung in association with pulmonary fibrosis in patients with rheumatoid arthritis (RA) with a particular focus on neutrophil and macrophage dysregulation. This position will be responsible for independently designing and conducting experiments that will establish the effect of specific proteins of interest on various lung cells obtained from human subjects with RA-associated interstitial lung disease (RA-ILD). The project will focus on the effects of citrullinated proteins, bacterial proteins and cytokine signaling pathways that have been previously identified to be of interest based on Dr. Demoruelle's prior studies. Cells of interest include neutrophils, macrophages and fibroblasts from the lung. The project will primarily use induced sputum samples from human subjects and human-derived cell lines along with cell culture, cell staining, and ELISA techniques. The project will compare changes induced in different lung cells between RA patients with and without ILD.

Specific Examples of Work

General daily activities:
    Plan and conduct day-to-day experimental activities related to the research project Collect, prepare and analyze research data including summarizing findings for publication of results Search pertinent scientific literature as needed Ensure quality control of all experiments and reagents Retain accurate records of research findings, along with analysis of results, in a detailed up-to-date electronic laboratory notebook Follow safe laboratory practices including BSL2+ level procedures for processing of human sputum samples Maintain clean and organized lab space Communicate effectively and collaboratively with other members of Dr. Demoruelle's research team

Ex vivo experiments:
    Isolate neutrophils and macrophages from induced sputum samples from human subjects using flow cytometry, microfluidics and other techniques Initiate and maintain primary and secondary cell cultures Stimulate cells in culture with multiple stimuli and inhibitors, including appropriate positive and negative controls, and quantify cell production of multiple cytokines and proteins Perform Western blot to measure activation of intracellular signaling pathways Perform immunostaining and RNA sequencing to determine changes in cell phenotype and function Establish protocols and optimal conditions for cryopreservation of cells

In vitro experiments:
    Perform ELISA and multiplex assays to measure cytokine and antibody levels Develop new ELISA assays to measure antibody reactivities to proteins of interest

General lab skills:
    Sputum and blood processing ELISA and multiplex assays Cell culture Western blot RT-PCR Immunofluorescence microscopy Flow cytometry

Special conditions of employment:
    Irregular hours may be necessary for some experiments.

Salary and Benefits

The salary range (or hiring range) has been established at $54,840- $66,600

The salary of the finalist(s) selected for this role will be set based on a variety of factors, including but not limited to, internal equity, experience, education, specialty and training.

The above salary range (or hiring range) represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Benefits: https://www.cu.edu/employee-services/benefits

Total Compensation Calculator: http://www.cu.edu/node/153125

Diversity and Equity:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at [email protected]​.

The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities, persons within the LGBTQ+ community, and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

The University of Colorado Denver | Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.


Qualifications
Minimum Requirements

Applicants must meet minimum qualifications at the time of hire.

Graduation from an accredited college or university with an MD or PhD

Minimum of 3 years' experience working in a wet laboratory with basic laboratory skills

Experience with cell culture, cell staining and Western blot techniques

Desired or preferred

Experience with flow cytometry, RNA sequencing, immunofluorescence microscopy and ELISA assay development

Experience with Microsoft Word, Excel, Powerpoint, and Graphpad Prism

Knowledge, skills, and abilities

Excellent organizational skills

The ability to work independently within the research lab




Special Instructions to Applicants: Review of applications will begin immediately and will continue until the position is filled. Applications are accepted electronically ONLY at www.cu.edu/cu-careers. Refer to requisition number: 27283. Application Materials Required: Cover Letter, Resume/CV, List of References, Additional Attachments - Refer to Application Materials Instructions Below Application Materials Instructions: Required Application Materials: To apply, please visit: http://www.cu.edu/cu-careers and attach: 1. A letter of application which specifically addresses the job requirements and outlines qualifications 2. A current CV/resume 3. List of five professional references (we will notify you prior to contacting both on and off-list references) Please be advised that the University does check references as part of the employment process. Please do not submit any of your application material (via email) to the job posting contact.

Job Category: Faculty

Primary Location: Aurora Department: U0001 -- DENVER & ANSCHUTZ MED CAMPUS - 20229 - SOM-MED-RHEUM GENRL OPERATIONS

Schedule: Full-time

Posting Date: Aug 31, 2022

Unposting Date: Ongoing Posting Contact Name: Carissa Figal Posting Contact Email: [email protected] Position Number: 00801086





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