Post Doctoral Fellow, Cancer Biology

Current UC employees must apply internally via SuccessFactors > http://bit.ly/UCEMPL

Founded in 1819, the University of Cincinnati ranks among the nation’s best urban public research universities. Home to more than 47,000 students, 10,500 faculty and staff and 330,000 alumni, UC combines a Top 35 research university with a physical setting The New York Times calls “the most ambitious campus design program in the country.”

With the launch of Next Lives Here, the Cincinnati Innovation District, a $100 million JobsOhio investment, eight straight years of record enrollment, worldwide leadership in cooperative education, a dynamic academic health center and entry into the Big 12 athletic conference, UC’s momentum has never been stronger. UC’s annual budget tops $1.6 billion and its endowment totals $1.9 billion.

Job Overview

As one of the oldest medical schools in the country, the UC College of Medicine has a reputation for training best-in-class health care professionals and developing cutting-edge procedures and research that improves the health and clinical care of patients.

The Department of Cancer Biology at the University of Cincinnati has an opening for a Postdoctoral Fellow supported by NCI R01 grants to study transcriptional and epigenetic gene regulation in breast cancer metastasis and therapeutic resistance. The Zhang laboratory (https://med.uc.edu/zhanglab) currently focuses on elucidating the role and molecular mechanisms of gene- and tissue-specific transcriptional cofactors and small RNAs (e.g. miRNA, enhancer RNA) in these processes in breast cancer cells and tumor microenvironment [ACS Nano (2017) 11(1):335, Cancer Research (2018) 78(2):422, Estrogen Receptor and Breast Cancer – Celebrating the 60th Anniversary of the Discovery of ER (1st ed, 2019, Springer Nature), Dev Cell (2021)56(3):341, Cell Reports (2021) 34(10):108822]. We are using a combination of biochemical, molecular, multi-omics, and mouse genetic (conditional knockout, mutant knockin, and overexpression) approaches. We are also currently developing RNA-based nano-therapeutics to target these cofactors and small RNAs to overcome the therapeutic resistance of human breast cancer.

Essential Functions
  • Perform and conduct the research required by the faculty supervisor to a high standard and in accordance with all institutional and federal regulations.
  • Prepare data reports, manuscripts and presentations of research results and assist in grant writing.
  • Keep informed of developments in field to maintain and enhance professional expertise.
  • Engage in appropriate training and professional development opportunities and play an active role in seeking career and research advice.
  • Perform related duties based on departmental need. This job description can be changed at any time.
Required Education

Doctoral Degree in Biochemistry, Molecular and Cellular Biology, or a related field.

Additional Qualifications ConsideredPrior experience with animal studies, small RNAs, or tumor microenvironment is a plus.

Compensation and Benefits

UC offers a wide array of complementary and affordable benefit options, to meet the financial, educational, health, and wellness needs of you and your family. Eligibility varies by position and FTE.

  • Competitive salary range dependent on the candidate's experience.
  • Comprehensive insurance plans including medical, dental, vision, and prescription coverage.
  • Flexible spending accounts and an award-winning employee wellness program, plus an employee assistance program.
  • Financial security via our life and long-term disability insurance, accident and illness insurance, and retirement savings plans.
  • Generous paid time off work options including vacation, sick leave, annual holidays, and winter season days in addition to paid parental leave.
  • Tuition remission is available for employees and their eligible dependents.
  • Enjoy discounts for on and off-campus activities and services.

The University of Cincinnati, as a multi-national and culturally diverse university, is committed to providing an inclusive, equitable and diverse place of learning and employment. As part of a complete job application you will be asked to include a Contribution to Diversity and Inclusion statement.

As a UC employee, and an employee of an Ohio public institution, if hired you will not contribute to the federal Social Security system, other than contributions to Medicare. Instead, UC employees have the option to contribute to a state retirement plan (OPERS, STRS) or an alternative retirement plan (ARP).

The University of Cincinnati is an Affirmative Action / Equal Opportunity Employer / Minority / Female / Disability / Veteran.

REQ: 88627

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