Postdoctoral Research Associate - Cell Biology - Biomedical & Nutritional Sciences
- Employer
- University of Massachusetts Lowell
- Location
- UMass Lowell
View more
- Position Type
- Postdoc
- Employment Type
- Full Time
- Institution Type
- Four-Year Institution
Job Details
Position type: Staff Full Time
Benefit Status: Benefited-Union
Campus: UMass Lowell
Department: Biomed & Nutritional Sciences
Salary: Salary commensurate with experience and grant
Applications Open: Jun 17 2022
Applications Close: Open until filled
General Summary of Position:
The interactions between immune cells, epithelium and stressors determine the inflammation status of a host. It is widely accepted that the chronic inflammation is linked to several metabolic diseases including inflammatory bowel disease, atherosclerosis, obesity, and cancers. In the current project, we will use the normal and tumor enteroid model where enteroids mimicking the in vivo epithelial cells will be isolated from human intestine after surgical resection or from the biopsies. Several microbial products will be used as a stressor to test their effect in the integrity of the gut barrier and micronutrients will be used to determine their preventive effect. If the gut barriers are disrupted, then the harmful components can cross the epithelial layer and can interact with phagocytes including macrophages. The role of macrophages will be assessed in different disease stages. Primarily the transcriptomic and proteomic datasets will be used, and the predicted candidates will be validated in the patient-derived blood monocytes and tissue specific macrophages. This study will advance our understanding of the role of epithelial-immune cell crosstalk in chronic diseases including cancers and enhance our ability to design new targeted therapy.
Minimum Qualifications (Required):
Education:
- PhD in cell biology, biochemistry, and related fields AND track record of publications on cancer and immunology (must have Ph.D. by the time of appointment)
Experience:
- A strong background and research experiences in biochemistry, immunology, and cell biology
- A research background in the application and/or knowledge in primary cells, isolation of monocytes from blood and stem cell biology would be useful
Skills:
- Ability to work as a team player
- Strong technical report writing and communication skills
- Quantitative research methods and statistics
Special Instructions to Applicants:
Only current UML Employees within the Grants & Contracts (MTA/GRACE) bargaining unit will be considered during the first 10 business days of the posting. All other candidates will be considered after that period.
Initial review of applications will begin immediately and continue until the position is filled. However, the position may close when an adequate number of qualified applications is received.
This position is contingent upon funding. The initial appointment will be for one year with a possibility of renewal based on productivity, successful performance and the availability of funding.
Please include a resume and cover letter with your application. Names and contact information of three references will be required during the application process.
Organization
Working at University of Massachusetts Lowell
Located in the culturally and historically rich Merrimack.
Valley in northeast Massachusetts, the University of Massachusetts Lowell is a vibrant research university that offers its 13,000 students more than 120 bachelor’s, master’s, professional master’s and doctoral degree programs. Exciting opportunities in experiential and service learning, scholarship, community engagement, and international partnerships can be found across the Colleges of Fine Arts, Humanities and Social Sciences; Engineering; Management; Sciences; School of Health and Environment; and Graduate School of Education.
This is a time of unprecedented growth and opportunity at UMass Lowell. Student enrollment and retention have improved annually. Research funding and alumni giving have increased significantly and the campus has embarked on the construction of two new academic buildings: the Emerging Technologies & Innovation Center and the Health & Social Sciences Building.
The University of Massachusetts Lowell is committed to increasing diversity in its faculty, staff, and student populations, as well as curriculum and support programs, while promoting an inclusive environment. We seek candidates who can contribute to that goal and encourage you to apply and to identify your strengths in this area.
Mission Statement
The mission of the University of Massachusetts Lowell is to enhance the intellectual, personal and cultural development of its students through excellent, affordable educational programs. The University seeks to meet the needs of the Commonwealth today and into the future and supports the development of sustainable technologies and communities through its teaching, research, scholarship and engagement.
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