Postdoctoral Fellow, Immunobiology and Microbial Pathogenesis, Dr. Daniel Hollern

Employer
Salk Institute for Biological Studies
Location
La Jolla, CA

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Faculty Jobs
Health & Medical, Medicine
Position Type
Postdoc
Employment Type
Full Time
Institution Type
Four-Year Institution

Job Details

The laboratory of Dr. Daniel Hollern at the Salk Institute of Biological Studies Department of Immunobiology and Microbial Pathogenesis in La Jolla, California seeks to recruit a Postdoctoral Fellow to engage in immuno-oncology research.

The main focus of the lab is to understand the immunological and molecular landscape of tumors with the goal of leveraging the immune component to promote anti-tumor immunity. In more detail, the lab is particularly interested in developing these approaches through the study of tumor infiltrating B cells and T cells. These studies will be pursued in syngeneic, orthotopic and genetically engineered mouse models as well as patient specimens.  The lab utilizes a multidisciplinary approach blending biologically appropriate models, molecular biology, and genomic analytical techniques including single cell and spatial transcriptomics and proteomics to interrogate pertinent questions in a number of in vitro and in vivo translational studies of breast cancer.

Position Highlights:

  • Be involved in exciting projects to understand B cell and T cell immunobiology in solid cancers and studies exploring novel immunotherapeutic strategies.
  • Conduct independent and collaborative studies in an Immunology lab focusing on clinically-relevant translational studies.
  • Opportunity to learn techniques in single-cell and spatial computational genomics and immuno-oncology by projects investigating beneficial patient outcomes and anti-tumor immunity.
  • Opportunity to develop new models for immune-oncology research.
  • Participation at scientific meetings, membership in relevant scientific organizations, and applying for training grants will be encouraged and supported.

Ideal Candidate:

  • Experience with analysis of genomic datasets such as RNA-seq, spatial datasets and single cell sequencing.
  • Experience working with lab animals and expertise in the following cellular biology techniques:
    • Murine syngeneic and genetically engineered models of cancers as well as allografts/xenografts
    • Multi-parameter flow cytometry
    • Cell culture
    • Elispot or Luminex-based assays for cytokine/chemokine assessments.
    • Immunofluorescent staining, imaging and fluorescent microscopy.
  • Experience with standard molecular biology assays and genome editing (Crispr).
  • Experience with proven record of publications in reputable journals, preferred.

Responsibilities:

  • Perform investigational studies to understand the tumor microenvironment.
  • Execute experiments independently and contribute to collaborative projects.
  • Write grants.
  • Write manuscripts for publishing.
  • Train and supervise junior staff and participate in overall lab management.
  • Analyze and present data at local and national meetings.

Credentials and Qualifications:

Ph.D. in Immunology, Cellular/Molecular Biology, or related fields. M.D. are welcome to apply. Hands-on-experience in laboratory research and good computer skills are required.

Organization

Working at Salk Institute for Biological Studies

The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused on both discovery and mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes, and cardiovascular disorders by studying neuroscience, genetics, cell and plant biology, and related disciplines.

Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.

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The Salk Institute for Biological Studies is committed to providing equal access to opportunities for students, employees, applicants for employment and other persons.

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