Sr. Research Specialist
We are seeking a Senior Research Specialist
will join the research program in the Suresh and Shimoda labs at the Johns Hopkins Department of Medicine to perform basic laboratory research on pulmonary physiology and pathobiology related to pulmonary hypertension. Our lab uses animal models and cells derived from human patients. Specifically, we use in vivo and in vitro approaches to examine cellular derangements, including metabolism, proliferation, apoptosis and migration and explore the signaling mechanisms underlying these changes. As part of the study team, will collaborate with the Principal Investigators (PIs) to design new assays to measure cellular outcomes and execute previously established protocols for the measurement of various intracellular signaling pathways using a combinatorial approach of fluorescent and confocal microscopy in fixed tissue and live and fixed cells, standard and advanced molecular biological techniques, isometric tension recording and cell-based proliferation and metabolic assays.
With limited supervision by the PIs, this individual will design and perform laboratory experiments on his or her independent research projects. Responsible for developing and organizing data reports and writing scientific papers resulting from the research projects. Provide day-day supervision and train junior postdoctoral fellows and students on the techniques and skills needed in the lab. Collaborate with the PI in overseeing the administrative and scientific implementation of the research protocols. With appropriate direction by the PI, functions as a leader in maintaining and circulating research protocols among the program members, setting agendas and schedules for routine research-related meetings and other activities, processing laboratory protocols for the lab research program. Specific Duties & Responsibilities:
- Participate in laboratory research in a comprehensive pulmonary vascular research program, and develop and design research protocols to investigate molecular mechanisms of cell function and phenotype, investigate metabolic pathways and assess in vivo and in vitro pulmonary vascular function.
- With limited guidance by the principal investigator (PI), develop and define research projects and strategies. The ideal candidate will have experience in assay development, including troubleshooting and optimization.
- Independently design and perform laboratory experiments for specific research projects in the lab.
- Use special skills and expertise to prepare and apply cells, vessels, and tissue from animal models to pulmonary vascular research.
- Organize, analyze and summarize the research data to prepare laboratory and scientific meeting reports.
- Must have experience using Excel, ImageJ and PowerLab for primary analysis of data.
- Present data at meetings.
- Write/draft scientific manuscripts for publications from the research projects.
- Participate as a member of collaborative group study team in study design and development of vascular research projects.
- Ability to design/fix lab equipment. Many of our experiments require specialized, custom built rigs, including systems for isolated vessel experiments, hypoxia chambers, reactive oxygen species measurements, etc.
- The ideal candidate will have experience building and maintaining/repairing custom systems for these types of measurements, as well as skills to assist with development of future systems.
- Works with the PI to prepare and submit annual IACUC renewals and amendments.
- Maintains excellent working knowledge of all assigned study protocols.
- Train research staff on job functions and performs quality assurance reviews for the scientific data.
- Designs spreadsheets and databases for tracking and management of research data.
- Performs literature searches for presentations, and publications.
- Ensures accuracy and timeliness of data collection.
- Interacts regularly with members of the research team regarding data management and the status and progress of ongoing studies.
Minimum Qualifications (Mandatory):
- Meets regularly with the PI and other senior members of the team to discuss study progress. Participates in all mandatory meetings of the research program and helps to prepare material for these meetings.
- Prepares reports as required by the principal investigators and senior scientists on the program.
- Is highly experienced and knowledgeable and complies with all standard laboratory research protocols, regulations, and policies; may instruct introductory level research personnel in these guidelines and policies.
- Requires a minimum of a Bachelor's Degree in Biology, Chemistry, or other related science, and at least four years of experience and expertise in laboratory management.
* Applicants who do not meet the posted requirements but are completing their final academic semester/quarter will be considered eligible for employment and may be asked to provide additional information confirming their academic completion date. Special Knowledge, Skills & Abilities:
- Able to perform scientific research through conducing laboratory experiments using a variety of techniques, such as cell culture, isometric tension recording, live cell microscopy, confocal microscopy, and others.
- Skills and expertise in isolating and handling pulmonary blood vessels and developing animal models of pulmonary hypertension.
- Proficiency in the use of software applications, databases, spreadsheets, and word processing required.
- Excellent organizational, attention to detail, and time management skills required. Knowledge of vascular physiology research and principles required.
- Actual strong research experience is required.
- Able to manage multiple and competing priorities.
- Have excellent communication skills.
- Sitting in a normal seated position for extended periods of time.
- Reaching by extending hand(s) or arm(s) in any direction.
- Finger dexterity to manipulate objects with fingers rather than with whole hand or arm, for example, using a keyboard.
- Communication skills using the spoken word.
- Ability to see within normal parameters.
- Ability to hear within normal ranges.
- Ability to move about.
- Supervises the junior personnel (typically 1-3 students or junior trainees—e.g., students and junior postdoctoral fellows) to provide them technical assistance and operational advice on vascular research assays.
- Trains these personnel and is involved in performing experiments, data collection and data entry as well as provides resource support to other personnel for unplanned problems.
- Help interview, hire and manage performance of the personnel in the lab research program.
Classified Title: Sr. Research Specialist
Starting Salary Range: $45,650 - $62,850 annually (commensurate with experience)
Employee group: Full Time
Schedule: Monday - Friday; 40 hrs
Exempt Status: Exempt
Location: School of Medicine Campus
Department name: SOM DOM Pulmonary
Personnel area: School of Medicine
The successful candidate(s) for this position will be subject to a pre-employment background check.
If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the Talent Acquisition Office at [email protected]
. For TTY users, call via Maryland Relay or dial 711.
Johns Hopkins has mandated COVID-19 and influenza vaccines, as applicable. Exceptions to the COVID and flu vaccine requirements may be provided to individuals for religious beliefs or medical reasons. Requests for an exception must be submitted to the JHU vaccination registry. For additional information, applicants for SOM positions should visit https://www.hopkinsmedicine.org/coronavirus/covid-19-vaccine/
and all other JHU applicants should visit https://covidinfo.jhu.edu/health-safety/covid-vaccination-information/
.The following additional provisions may apply, depending on campus. Your recruiter will advise accordingly.
The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.Equal Opportunity Employer
Note: Job Postings are updated daily and remain online until filled. EEO is the Law
To apply, visit https://jobs.jhu.edu/job/baltimore-Sr_-Research-Specialist-MD-21287/882183000/
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