Postdoctoral fellow or Research Associates in iPSC, Microglia Biology, Neuroimmunology, Molecular Neurobiology and in vivo Electrophysiology Neural Circuitry of Alzheimer’s Disease Tracking Code2853Job Description
Immediately available, multiple NIH funded, private foundation funded
The TCW laboratory (https://sites.bu.edu/tcwlab/) in the Department of Pharmacology and Experimental Therapeutics at Boston University School of Medicine in Boston, Massachusetts is looking for highly motivated and skilled molecular and cellular biologists or stem cell biologists to be the drivers of our efforts to translate the genetics of human AD toward therapeutic interventions. The Farb laboratory (https://www.bumc.bu.edu/busm-pm/faculty/faculty-profiles/farb/) seeks electrophysiologists with prior experience in neural circuitry level silicon probe/nanopixel high density in vivo electrophysiology, miniscopes, and/or optogenetics. The TCW and Farb laboratories have an ongoing, funded collaboration spanning the scope of research described and seek two dedicated fellows to join our leadership team.
The core program is to translate AD genetics and functional genomics into human brain cells both in vitro 2D and 3D models using human induced pluripotent stem cells (hiPSCs) both population and isogenic lines generated by CRISPR/Cas9 genome editing and in vivo (hiPSC/rodent chimera) systems in comparison with post-mortem brain. In particular, the research will focus on deciphering the molecular mechanism of major AD risk variants as well as protective variants, associated genes including APOE, TREM2, CD33 in brain and identifying targeted therapeutics based on our in vivo circuitry level research platform combined with automated behavioral measurements to assess memory. The candidate will join a multidisciplinary and highly collaborative research team that includes computational geneticists, neuroscientists and pharmacologists in the department as well as Genome Science Institute and Center for Systems Neuroscience at Boston University.
DO NOT APPLY THROUGH THE BOSTON UNIVERSITY CAREERS WEBSITE.
- Cover letter (required), CV with reference contact (required), major publications (optional), indicate your interest on projects under Any comments section or on the cover letter.
Submit the package to https://sites.bu.edu/tcwlab/talent-aquisition/
- 2-3 reference letters should be directly sent to the contacts below.
Contact or Any inquiry
Dr. Julia TCW, Assistant professor and Director at [email protected]
Dr. David Farb, Professor and Chair at [email protected]
First round of interview starts from May 1st. The job will be opened until the position is filled.
Please note all newly hired staff and faculty, will need to be in compliance with Boston University’s COVID-19 Vaccination and Booster Requirement within 30 days of date of hire. You must upload your vaccine documentation or request a medical or religious exemption (instructions). For further information on the University’s response to COVID-19, please visit the Back2BU site.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristic protected by law. We are a VEVRAA Federal Contractor.
Job LocationBoston, Massachusetts, United StatesPosition TypeFull-Time/Regular