Staff Research Associate III - 114693

Employer
University of California - San Diego
Location
La Jolla, CA

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Employment Type
Full Time
Institution Type
Four-Year Institution

UCSD Layoff from Career Appointment: Apply by 02/22/22 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants: Apply by 03/03/22. Eligible Special Selection clients should contact their Disability Counselor for assistance.

This position will remain open until filled.

DESCRIPTION

The multi-disciplinary laboratory within the Department of Pediatrics works in the fields of RNA and Chemical biology. The laboratory explores the role of RNA modifications in cancer, immunity, and stem cell biology. Projects in the lab use cell culture, animal models, neural stem cells, 3D organoids, human pluripotent cells and several molecular tools to investigate fundamental mechanisms of cancer development, AIDS, COVID, and immune disorders.

Under general supervision of the Principal Investigator, the Staff Research Associate III will perform cellular and animal lab experiments, making significant independent contributions in the design, troubleshooting, modification and analysis of experiments and protocols. Incumbent will also perform experiments using tissue culture techniques such as PCR, plasmid purification, iPSC production and characterization, and HT screening and sequencing, gene silencing, cloning, CRISPR genome editing, cancer models, drug treatments, under general supervision. In addition, the incumbent will independently support duties to include RT-PCR, qPCR, DNA and RNA molecular experiments, western blotting, immunoprecipitation, affinity purification, analyze and report data, prepare complex solutions, reagents and culture media and run cell analyses to ensure quality and control.

The incumbent will be responsible for implementing and performing a variety of new and on-going experimental protocols, making significant research contributions to the laboratory and making innovative contributions pertaining to complex experimental procedures of iPSC production and characterization. May provide training and direction and work cooperatively with other SRAs, including doctoral and student lab assistants. Compile and analyze research data, draft articles and grant proposals.

MINIMUM QUALIFICATIONS
  • Advanced theoretical knowledge of and direct experience with Stem Cell biology as typically attained by a Bachelor's degree or an equivalent combination of education and experience.

  • Strong experience with research design, protocol development, and qualitative and quantitative research methods to independently address scientific challenges to move the project forward.

  • Direct experience overseeing research projects.

  • Demonstrated experience authoring journal articles, abstracts, and posters. Ability to prepare papers for publication and research proposals. Ability to read, comprehend and discuss research materials. Review the scientific articles and make innovative contributions to develop new research techniques and improve current protocols for the research projects.

  • Proven knowledge of microscopy imaging procedures and in vivo analysis.

  • Strong experience in analysis and management of complex data.

  • Strong demonstrated experience in qualitative research methods.

  • Proficiency in the use of computer based spreadsheet, database, word processing communications and statistical applications (e.g., EXCEL, SPSS, ACCESS, WORD, ENDNOTE, POWER POINT, SAS).

  • Proven ability to perform scientific procedures including confocal microscopy, DNA and RNA isolation, and histological analysis.

  • Advanced knowledge and experience working with and handling small animals including mice. Knowledge of normal physiological data of rodents, particularly mice. Experience with small animal husbandry and excellent organizational skills to manage all lab animal work.

  • Knowledge of laboratory safety including radioactive/biohazard handling and disposal techniques, and the ability to ensure laboratory compliance with required safety regulations.

PREFERRED QUALIFICATIONS
  • Ph.D. in cell biology, biochemistry, chemical biology, or genetics.
SPECIAL CONDITIONS
  • Employment is subject to a criminal background check.
  • Occasional evenings and weekends may be required.
  • Must be willing to work with hazardous materials.
  • Must have access to reliable transportation.
  • Must be willing to work with small animals.

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