Job Code and Payroll Title
009611 SRA 3
The Staff Research Associate III (SRA III) assists the principal investigator (PI) with active experiments and the daily tasks related to the operation of a biomedical research laboratory. There is potential to eventually assume the role of lab manager.
Our research seeks to understand how cells, tissues, and organisms respond and adapt to low and high oxygen states at the molecular and whole-body physiology levels. We utilize a variety of in vitro (cell) models and mouse models to investigate specific transcription factors, gene and protein regulatory pathways, and metabolic changes in mediating responses under hypoxia and hyperoxia. This work lies at the intersection of hypoxia signaling, fatty acid and cholesterol metabolism, and cardiovascular disease. We use various biochemical assays, “multi-omics,” and computational approaches to carefully dissect mechanisms of hypoxia adaptation. We believe that this work will have broad implications for cardiovascular disease, including hyperlipidemia and ischemia-reperfusion injury.
The SRA III will have many duties relevant to these goals and it is expected that they will become increasing independent over time. It is expected that the SRA III will become well-versed in multiple molecular and biochemical techniques to analyze tissues and cells, such as western blotting, qPCR, and generation of DNA constructs. They will also assist with various mouse model experiments and take an active role in mouse colony maintenance.
Staff Research Associate III
Additional Shift Details
Monday-Friday 8AM-5PM, occasional weekends
University Professional Technical Employees – Research Support Professionals Unit (UPTE-RX)
Research and Scientific
• BA/BS degree with a major in a related science field (background in general biology, molecular biology, cell biology, genetics, and chemistry) and two or more years of recent, directly related work experience following degree completion, utilizing the techniques or methods required by the position and demonstrating technical expertise in these areas; or an equivalent combination of education and experience
• Experience with mouse colony maintenance and mouse breeding
• Experience with basic molecular cloning and biochemistry
• Experience with basic cell culture techniques
• Experience accurately and successfully performing DNA and protein gel electrophoresis; western blotting; PCR; quantitative RT-PCR; standard cell culture; and DNA/RNA extractions from animal tissues and cell culture samples
• Demonstrated knowledge of molarity, sterile technique, standard Mendelian genetic inheritance, and general microbiology
• Demonstrated ability to perform standard data analysis
• Demonstrated ability to multi-task
• Master’s degree in a field relevant to biomedical research
• Experience with rodent handling and experiments, including delivery of compounds via tail vein injection, intra-peritoneal injections, and oral gavage
• Previous research assistant or lab manager experience
Equal Employment Opportunity
The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.
The Jain laboratory is focused on understanding oxygen metabolism with the ultimate goal of developing novel therapies for various metabolic conditions. The lab uses a combination of genomics, systems metabolism, and animal physiology approaches to achieve these goals. Dr. Jain previously discovered that chronic hypoxia (equivalent to 4500m altitude) could extend the life of mitochondrial disease animal models by five-fold. The lab is focused on understanding why too little (hypoxia) and too much (hyperoxia) oxygen is toxic and how these states affect disease progression. We hope to apply our findings to pathologies ranging from mitochondrial disease to cardiovascular disease to aging.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.
UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as our PRIDE values.
In addition to our PRIDE values, UCSF is committed to equity – both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available at diversity.ucsf.edu
Join us to find a rewarding career contributing to improving healthcare worldwide.
Mission Bay (SF)