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Duke University
Neuro Oncology

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Position Type
Employment Type
Full Time
Institution Type
Four-Year Institution
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Job Details

School of Medicine:

Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.

Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

Postdoctoral Associate

The Ashley Laboratory is seeking a postdoctoral associate to join our neuro-oncology research program. This role will lead collaborative projects related to the interplay between glioma-associated genetic mutations, DNA damage, and the induction of inflammation in the glioma microenvironment.

Our studies focus on the role of inflammatory signaling in malignant gliomas, with an emphasis on the identification and validation of novel immunotherapeutic strategies. We use a diverse combination of experimental approaches, including next-generation DNA/RNA sequencing, genetically engineered cell lines, and mouse brain tumor models to understand the molecular mechanisms underlying brain tumor biology and anti-tumor immunity. Our overarching goal is to use novel biological insights to deliver better therapies and care to brain tumor patients.

The ideal candidate will have at least 3-5 years of research experience in cellular and molecular biology and mouse models of disease. Candidates should have a proven track record of peer-reviewed first-author publications in respected journals. Previous experience in cancer biology, pharmacology, bioinformatics, and cancer genomics would be helpful. We also encourage candidates who are trained in other fields, such as developmental biology, immunology, and neuroscience, to apply these positions if they feel their skill sets are translatable to the goals described above. Strong mentoring support is available from Dr. Ashley and senior faculty in the Duke Brain Tumor Center to write and win highly competitive postdoctoral grants, including track records of success with trainees winning F32, K22, and K99 grants.


  • Doctoral degree in molecular biology with an emphasis on cancer cell biology.
  • Minimum 3-5 years of life science research experience.
  • Experience working with mouse models of disease, especially brain tumor models
  • Technical aptitude for learning and executing complex experimental techniques for molecular biology, cell-based assays, and rodent procedures.
  • Ability to adapt to unforeseen challenges and act with urgency to resolve critical project issues.
  • Ability to handle administrative responsibilities (e.g. ordering, inventory) as needed.
  • Impeccable experimental documentation and organized record-keeping skills, ideally with experience using an electronic notebook.
  • Familiarity with the development of laboratory protocols for SOPs, grants, IACUC, IBC and IRB documents.
  • Ability to effectively work independently and in a team environment in a fast-paced lab.

Responsibilities include:

  • Conduct a variety of investigations including planning, development, and implementation of experimental procedures as well as data analysis under supervision of senior scientists to contribute to research projects in the Tisch Brain Tumor Center at Duke.
  • Independently perform bench work and mammalian cell culture/cell-based assays of tumor cell growth and response to therapeutic agents.
  • Learn and conduct mouse surgeries and subsequent animal health monitoring for intracranial tumors models.
  • Prepare common lab solutions, reagents, and tissue specimens for complex procedures.
  • Evaluate and interpret collected data and prepare reports and analyses setting forth progress, adverse trends, and appropriate recommendations or conclusions.
  • Review scientific literature to keep abreast of new developments and to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques.
  • Maintain up-to-date laboratory inventories of critical reagents/chemicals, cell lines, plasmid constructs, supplies, etc., and ordering additional items as needed.
  • Assist with writing large research grants (e.g. NIH R01) and independently write and submit (with appropriate mentorship) postdoctoral fellowship grants to NIH (e.g. F32) and foundations.
  • Communicate scientific results to colleagues, mentors, and the broader scientific community

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.


Read our Diversity Profile History

Duke University was created in 1924 by James Buchanan Duke as a memorial to his father, Washington Duke. The Dukes, a Durham family that built a worldwide financial empire in the manufacture of tobacco products and developed electricity production in the Carolinas, long had been interested in Trinity College. Trinity traced its roots to 1838 in nearby Randolph County when local Methodist and Quaker communities opened Union Institute. The school, then named Trinity College, moved to Durham in 1892, where Benjamin Newton Duke served as a primary benefactor and link with the Duke family until his death in 1929. In December 1924, the provisions of indenture by Benjamin’s brother, James B. Duke, created the family philanthropic foundation, The Duke Endowment, which provided for the expansion of Trinity College into Duke University.Duke Campus

As a result of the Duke gift, Trinity underwent both physical and academic expansion. The original Durham campus became known as East Campus when it was rebuilt in stately Georgian architecture. West Campus, Gothic in style and dominated by the soaring 210-foot tower of Duke Chapel, opened in 1930. East Campus served as home of the Woman's College of Duke University until 1972, when the men's and women's undergraduate colleges merged. Both men and women undergraduates now enroll in either the Trinity College of Arts & Sciences or the Pratt School of Engineering. In 1995, East Campus became the home for all first-year students.

Duke maintains a historic affiliation with the United Methodist Church.

Home of the Blue Devils, Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world.

Mission Statement

Duke Science"James B. Duke's founding Indenture of Duke University directed the members of the University to 'provide real leadership in the educational world' by choosing individuals of 'outstanding character, ability, and vision' to serve as its officers, trustees and faculty; by carefully selecting students of 'character, determination and application;' and by pursuing those areas of teaching and scholarship that would 'most help to develop our resources, increase our wisdom, and promote human happiness.'

“To these ends, the mission of Duke University is to provide a superior liberal education to undergraduate students, attending not only to their intellectual growth but also to their development as adults committed to high ethical standards and full participation as leaders in their communities; to prepare future members of the learned professions for lives of skilled and ethical service by providing excellent graduate and professional education; to advance the frontiers of knowledge and contribute boldly to the international community of scholarship; to promote an intellectual environment built on a commitment to free and open inquiry; to help those who suffer, cure disease, and promote health, through sophisticated medical research and thoughtful patient care; to provide wide ranging educational opportunities, on and beyond our campuses, for traditional students, active professionals and life-long learners using the power of information technologies; and to promote a deep appreciation for the range of human difference and potential, a sense of the obligations and rewards of citizenship, and a commitment to learning, freedom and truth.Duke Meeting

 “By pursuing these objectives with vision and integrity, Duke University seeks to engage the mind, elevate the spirit, and stimulate the best effort of all who are associated with the University; to contribute in diverse ways to the local community, the state, the nation and the world; and to attain and maintain a place of real leadership in all that we do.”

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