Description

University of Colorado – School of Medicine

Post-Doctoral Fellow

 

The University of Colorado has a requirement for COVID-19 vaccinations and full completion thereof by 9/1/21 or upon start date.  Information regarding this requirement, and exemptions can be found at:

Anschutz: https://www.ucdenver.edu/docs/librariesprovider284/default-document-library/3000-general-admission/3012---covid-19-vaccination-requirement-and-compliance.pdf?sfvrsn=4e9df3ba_2

Denver: https://www.ucdenver.edu/coronavirus

Exemptions vary by campus location/department.

Campus/Unit-Specific Exemptions:

Anschutz Campus – Exemptions are allowed for medical or religious reasons.Denver Campus - Exemptions are allowed for medical, religious, or personal reasons.Consolidated/Central Services Administration – Will follow Anschutz policy on exemptions.

The University of Colorado Denver seeks individuals with demonstrated commitment to creating an inclusive learning and working environment.  We value the ability to engage effectively with students, faculty and staff of diverse backgrounds

The Cardiovascular and Pulmonary (CVP) research group in the Department of Medicine has a full time opening for a Postdoctoral Fellow in the Dr.Irwin laboratory. The selected applicant will be working in the area of cardiopulmonary (CPB) bypass / and extracorporeal membrane oxygenation, which also includes treatment of Adult Respiratory Distress Syndrome (ARDS). Projects will include: (1) testing oxygenated microbubbles (OMBs) delivery via intraperitoneal / colon administration to increase end organ oxygenation and be used as a bridge to increase survival in ARDS patients needing to rapidly transition to ECMO / CPB; and (2) develop an animal model mimicking prolonged CPB surgeries and testing novel therapeutic bioengineered proteins to protected against hemoglobin induced  toxicity from CPB-induced hemolysis. Specifically, the successful applicant will perform mechanistic and applied physiological studies  related to survival and end organ injury in cardiac events / surgeries. This work will include: (1) measurements of O2 supply ,blood gases, and metabolism of  red blood cells, local tissue, muscle, organs assessing oxygenation. Methods will also be used to assess noval OMB formulations, and to draw correlations with mass transfer properties and pharmacokinetics. Measurements of cardiac and pulmonary function as well as metabolomics, and histopathological analysis of lung, heart, kidney and liver to assess hemoglobin / iron toxicity in end organs after prolonged CPB surgeries.  

This is a collaborative research group the fosters team science and collaboration. Dr. Irwin works closely with the groups of Dr. Mark Borden of the University of Colorado Boulder and Dr. Paul Buehler at University of Maryland, Baltimore, Dr. Andre Palmer at The Ohio State University, and Dr. Pedro Cabrales at the University of California Sandiego. Combining the strengths of these labs by employing bioengineering  of OMB and hemoglobin and heme scavenger proteins,  physiological, molecular and translational approaches. Current projects include pulmonary and systemic administration of single and dual function scavenger proteins to rodent models of genetically aquired (sickle cell disease) and CPB pump- induced hemolysis, and how iron overloading in the macrophage alters the development and progression of PH in sickle cell anemia patients.

Supervision received:

The successful candidate will report directly Dr. David Irwin, but will also be mentored by Dr. Mark Borden (PI on the OMB project), who has a separate established lab on the University of Colorado, Boulder Campus. In addition, there will be interaction with Drs. Buehler,Palmer and Cabrales.

 Supervision Exercised: None

 Examples of work performed:

Perform experiments using advanced biomedical research techniques and develop new methods/applications.Trouble-shoot and problem-solve as related to the research projectTravel to Boulder Campus as necessary to coordinate OMB preparation with studies to be conducted in Dr. Irwin Lab. Record results of experiments: tabulate research data and maintain a detailed, easily understandable laboratory notebookInterpret experimental resultsCollaborate with PI and others in the lab as well as other laboratories involved in team scienceConduct literature searchesModify, test, verify and analyze research dataPresent results at lab meetingsPresent results at project meetings such as research in progressPresent results at (inter)national meetingWrite and publish manuscripts describing resultsPrepare grant applications, as necessaryPerform all research compliance activities required by the University of Colorado DenverOther related duties as assigned by PI

Salary Range:

The salary range (or hiring range) has been established at $53,760 to $65,292. 

 The salary of the finalist(s) selected for this role will be set based on a variety of factors, including but not limited to, internal equity, experience, education, specialty and training.

The above salary range (or hiring range) represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting.

 

The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services.

University of Colorado Denver | Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background checks for all new employees prior to their employment.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Benefits: https://www.cu.edu/employee-services/benefits.

Total Compensation Calculator: https://www.cu.edu/employee-services/total-compensation

Diversity and Equity:

Please click here for information on disability accommodations: https://www1.ucdenver.edu/offices/human-resources/employee-relations-performance/ada-compliance

Office of Equity: https://www1.ucdenver.edu/offices/equity

The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

Qualifications
Minimum qualifications:

A doctorate degree in life sciences such as Cancer Biology, Immunology, cell biology, molecular biology, or related field (degree must be conferred prior to starting position, but need not be completed at the time of application)Working knowledge of molecular biology.

Applicants must meet minimum qualifications at the time of hire.

Preferred requirements: 

Experience with transcription factors and chromatin structurePrior experience with analyses of “omics” data.

Job Category: Faculty
Primary Location: Aurora
Schedule: Full-time
Posting Date: Jan 4, 2022
Unposting Date: Ongoing