Research Assistant (Temporary), School of Biological and Chemical Sciences, 33565 Location:
UMKC Volker Campus Full/Part Time:
Full-Time Job ID:
School of Biological and Chemical Sciences; Mohan Laboratory
Job Description The Mohan Laboratory currently seeks to hire a Research Assistant.
A series of devastating neurodegenerative diseases arise from a similar genetic mutation (termed "polyQ expansion") in seemingly unrelated genes. The polyQ disease family includes Huntington's disease, Machado Joseph disease, Spinobulbar Muscular Atrophy, and a number of Spinocerebellar Ataxias. Interestingly, polyQ expansion is currently the best known predictor for susceptibility to Amyotrophic Lateral Sclerosis (ALS) (recall the ice bucket challenge to raise funds for ALS research).
The functions of the proteins subject to polyQ expansion are very poorly understood, but studies hint that regulation of gene expression is a common critical function for each. We aim to understand the molecular mechanisms through which polyQ expansion disrupts gene expression in these devastating diseases. Utilizing a combination of biochemical, genomic, genetic, and proteomic approaches, we are identifying essential pathways disrupted by polyQ expansion and determining which are able to rescue neurodegeneration in model organisms. Ultimately, we aim to reveal novel pathways suitable for treatment in patients.
Candidates will be author on publications to which they contribute and have the opportunity for promotion as their skills develop.
Successful candidate’s qualifications should include:
- a Bachelor’s degree in a related field
- should be familiar with one or more of the techniques used in the laboratory, which are diverse and include Drosophila work, fly husbandry, insect/mammalian tissue culture, protein purification, analysis of multi-protein complexes, molecular cloning, analysis of protein-protein interactions, enzymology, imaging, CRISPR/Cas9, immunoblotting, immunoprecipitation, immunostaining, confocal microscopy, microdissections, preparation of solutions, chromatography, preparation of lysates, and analysis of next-generation sequencing data
- a strong work ethic, excellent organizational and communication skills, and critical thinking abilities.
Full Time/Part Time
This role is a 6 month contract with option for renewal after that time. During the 6 months, this role will be a 1.0 FTE (40 hours per week) and will not be eligible for university benefits.
$18.26 - $20.19/hr commensurate with experience and education
Position is open until filled; review of candidates will begin immediately. For full consideration, please apply by January 3, 2022.
To be considered, you must complete the application which contains two (2) sections: 1. Name and Contact Information 2. Combine all application materials (a letter of interest, curriculum vitae, a list of at least five references) into one PDF or Microsoft Word document and upload as a resume attachment.
Limit document name to 50 characters. Maximum size limit is 11MB. Do not include special characters (e.g., /,&, %, etc.).
If you need technical assistance, please call (800) 488-5288.
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