Postdoctoral Researcher

Employer
The University of Kansas
Location
Lawrence, KS

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Position Type
Postdoc
Employment Type
Full Time
Institution Type
Four-Year Institution

Job Details

Position OverviewWe are currently seeking a highly motivated Postdoctoral Researcher to join the Biopharmaceutical Innovation Optimization Center (BIO Center). The ideal candidate will perform independent research associated with developing assays for drugs and their metabolites to support pharmacokinetic analysis by using LC/MS or LCMS/MS, will determine in vitro eADME (protein binding, microsome stability, plasma stability, lipophilicity) properties of drugs, develop chromatographic separation methods for drugs and their degradants from formulation media, develop assays to separate and monitor both in vitro and in vivo presence of prodrugs and their parent molecules, and execute chemical stability, physical stability and solubility studies. All duties will be performed under supervision of the Principal Investigator. The candidate must have experience with analytical chemistry, mass spectrometry, bioanalytical chemistry, HPLC/UV method development, and drug substance characterization. The candidate is responsible for developing bioanalytical methods for experimental drugs and metabolites using mass spectrometry. The candidate will also perform assay development and validation, and physical/chemical characterization of drug candidates using HPLC/UV methodology. The candidate will serve as an expert in the specialized research areas LCMS and HPLC.

The Biopharmaceutical Innovation and Optimization Center (BIO Center) provides drug delivery, solubilization, and stabilization services to researchers. The Center is located on the KU Lawrence West District campus in McCollum Research Laboratory. The BIO Center works with researchers at the University of Kansas and with experts around the world to transform new discoveries into products for patients. A large portion of the Centers research is conducted in partnership with the KU Cancer Center (KUCC). The KUCC is one of 67 NCI- designated Comprehensive Cancer Centers in the United States. Job Description50% Under supervision of the Principal Investigator, lead the development, design, and implementation of research plan to meet customer expectations. Identify and solve complex research problems. Write and review research protocols. Conduct research, working as part of a research team in scientific areas consistent with general research areas of the BIO Center and its affiliated researchers. Activities including operating skilled instrumentation per protocols and SOP’s (LCMS/MS, HPLC, Gas Chromatography), monitor output, and performs analysis of data. Conducts research, working as part of a research team and performs research related activities. Interacts with other researchers and collaborates on lab techniques, study methodology, and suggests new techniques.

20% Oversee the completion of data analysis and completion research reports for customers. Monitor the integrity of data collection and appropriate use of protocols, Standard Operating Procedures. Troubleshoot instrumentation maintenance and general repairs. Update documentation and analytical methodology used in support of formulations. Provide technical and/or research related support for performing a broad range of complex laboratory and/or research related tasks. Assist with training of other researchers in equipment use, study methodology, and data collection techniques. Identifies problems, recommends and implements solutions. Coordinates data collection and screening to verify data. Acquires and performs analysis of data. All duties performed under supervision of the Principal Investigator

15% Actively participate in the activities of the BIO Center including, but not limited to, participation in scientific seminars, participation in group meetings and relevant seminars, reporting progress for the benefit of reports, collaborating with Center scientists and presentation of scholarly work in appropriate local, regional, and national settings. Coordinate with others to refine or adapt methodologies to fit research requirements.

15% Conduct literature search and research activities independently in labs. Preparation of scientific manuscripts for publication and assistance in compiling data for filing patents and seminars including maintenance of detailed records of research and findings. All relevant data must be recorded in a laboratory notebook following a standard style utilized by the laboratory. Required Qualifications
  1. PhD with wet laboratory experience including sample manipulation and experimental design.
  2. At least 3-years experience developing assays for drugs and their metabolites for pharmacokinetic analysis and other complex biological media while using LC/MS/MS.
  3. At least 3-years experience in drug development research, including analytical chemistry, mass spectrometry, bioanalytical chemistry, and HPLC Chromatography.
  4. At least 3-years experience in evaluating stability and/or solubilization of experimental compounds for characterization and/or preparation of dosing solutions.
  5. Ability to perform periodic maintenance and repairs on LC, LCMS and Mass Spectrometry instrumentation as demonstrated through prior work experience.
Preferred Qualifications
  1. A record of published, peer-reviewed research in areas related to the analysis of biological data.
  2. Ability to manage and organize multiple research projects.
  3. Ability to work in a collaborative environment.
  4. Ability to work with thermal analysis equipment (DSC, TGA, DVS)
Additional Candidate InstructionsA complete application includes an online application, cover letter, resume highlighting pertinent experience relative to the required and preferred qualifications and contact information for three professional references. Only complete applications will be considered.

Application review will begin on November 29, 2021 and continue until a successful candidate is identified.
Contact Information to ApplicantsLanaea Heine
[email protected]
785-864-5141 Advertised Salary Range47,500.00 - 55,000.00 Commensurate with experience Application Review Begins29-Nov-2021 Anticipated Start Date01-Feb-2021

Organization

Working at the University of Kansas 

Join the University of Kansas, and you’ll become part of a Jayhawk family that spans the globe. Wear your KU shirt in London, Istanbul, Buenos Aires, Nairobi or anywhere else, and you will likely hear a resounding “Rock Chalk!” from a stranger. Of course, the appropriate response is an enthusiastic “Jayhawk!” Because, after all, they’re not really strangers, they’re family.

The Jayhawk community is united by more than 150 years of tradition and by our commitment to pushing the boundaries of knowledge, transforming the academic experience, and creating solutions through innovative research. KU’s mission is to lift students and society by educating leaders, building healthy communities and making discoveries that change the world.  

The University of Kansas is the state’s flagship university and one of just 66 invited members of the prestigious Association of American Universities (AAU). We consistently earn high rankings for academics and recognition as a premier research university.

KU faculty and staff embrace our role as the state’s flagship university, AAU member and R1 institution that serves the state, nation and world. We celebrate the energy and compassion that infuse the Jayhawk spirit; and, we remain true to KU’s historic values: the elevating force of education, the transformative power of research and the healing power of service.

Diversity, Equity, Inclusion, and Belonging 

The University of Kansas is committed to a learning and workplace environment that is representative of our nation and global society, accepts and values everyone, appreciates our common humanity and understands that our multiple differences are the cornerstone of academic preparation, professional excellence and distinction. KU must be a place where all people feel they belong and have access to resources and support that help them attain their educational and professional goals.

We recognize there are inequalities and privileges generated by historical and persistent intersecting differences by race, ethnicity, gender identities, gender expressions, sexual orientation, socio-economic status, age, abilities, religion, regional background, veteran status, citizenship status and nationality. And we hold ourselves accountable for policies, processes and programs that appreciate these and other differences and create more fair, safe and just learning, working and living environments for KU students, faculty and staff.

Instruction 

KU offers a broad array of undergraduate and graduate study programs, and we fulfill our mission through academic and research programs of international distinction, coupled with outstanding libraries, teaching museums and information technology. These resources enrich the academic experience for students from all 50 states and 112 countries, and provide enrichment resources for KU faculty and staff.

Research 

The university attains high levels of research productivity and recognizes that faculty are part of a network of scholars and academicians that shape a discipline as well as teach it. KU staff are integral to our research success, participating in and supporting discoveries that expand knowledge and improve lives.

Service 

The university and our employees serve society through research, teaching and the preservation and dissemination of knowledge. KU's academic programs, arts facilities and public programs provide cultural enrichment opportunities for the larger community. And, KU offers educational, research and service programs throughout the state. KU employees are encouraged to participate in and serve the campus and surrounding communities in a way that is meaningful to them.

International Dimension 

KU offers more than 100 programs of international study and cooperative research for KU students and faculty at sites around the world. The university offers teaching and research that draw upon and contribute to the most advanced developments throughout the United States and abroad. At the same time, KU's extensive international ties support economic development in Kansas.

Values 

The University of Kansas, our students and employees are committed to excellence. We foster a multicultural, inclusive environment in which the dignity and rights of individuals are respected. Intellectual diversity, integrity and disciplined inquiry in the search for knowledge are of paramount importance.

Our City and State 

KU sits atop Mt. Oread in the center of Lawrence, a town full of natural beauty and culture. In fact, Rolling Stone magazine named Lawrence one of the best college towns in the United States. Lawrence is home to more than 100,000 people, and has a charming, Midwestern friendliness that welcomes visitors and celebrates diversity. In addition to KU, Lawrence is home to Haskell Indian Nations University, the premiere tribal university in the United States.

Lawrence’s historic and thriving downtown features restaurants, nightlife and local shops offering unique finds that you won’t find anywhere else. The town has more than 50 parks, an encompassing mixed-use trail, and quick access to biking/hiking trails along the Kansas River and around Clinton Lake. A five-minute drive from Lawrence, Clinton Lake offers fishing, boating, beaches, camping and other outdoor activities.

Located just 40 minutes west of Kansas City, Lawrence offers the appeal of a mid-size, suburban town with quick access to the amenities of a large city, including an international airport. The Kansas City metro area is home to world-class museums and cultural activities, Jazz clubs and other nightlife venues, expansive shopping options, and exciting professional sports with the Kansas City Chiefs, Kansas City Royals and Sporting KC.

Kansas is in the center of the country, making it convenient and cost effective to fly or drive to destinations throughout the United States. Far from flat, the Flint Hills, just 90 minutes from Lawrence, offer panoramic vistas that showcase the breathtaking beauty of America.

Making KU Your Home 

Something about Lawrence is magnetic. Long-time residents are never surprised when a KU student or employee from out of state decides to make Lawrence their permanent home. And, even those who do leave often find themselves returning to “the nest” at some point in the future. In fact, Lawrence has been named by several publications as one of the best places to retire.

At the University of Kansas, you’ll join a global Jayhawk family and find a place to call home.

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