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Post Doctoral Associate - Physiology & Biophysics

University of Miami
Miami, FL

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Job location: Miami, FL

Employment Type: Full-time
Posted data: 2021-11-01
Req: R100052255
Current Employees:If you are a current Staff, Faculty or Temporary employee at the University of Miami, please click here to log in to Workday to use the internal application process. To learn how to apply for a faculty or staff position using the Career worklet, please review this tip sheet.

Transforming Lives

The University of Miami is among the top research universities and academic medical centers in the nation, and one of the largest private employers in South Florida.

With more than 16,000 faculty and staff, the University strives for excellence, and is driven by a powerful mission to transform and impact the lives of its students, patients, members of the community, and people across the globe.

The University is committed to fostering a culture of belonging, where everyone feels valued and has the opportunity to add value. Through values of Diversity, Integrity, Responsibility, Excellence, Compassion, Creativity, and Teamwork (DIRECCT) the U community works together to create an environment driven by purpose, excellence, community, and service.

The Department of Physiology & Biophysics has an exciting opportunity for a Postdoctoral Associate to work on the UHealth Campus. The Post Doctoral Associate performs scientific research and studies under the supervision of managing staff. The incumbent will work with Molecular Dynamics modeling of the SNARE complex and accessory proteins to elucidate the changes in protein interactions and conformations leading to vesicle fusion. For this position some experience with molecular dynamics simulations is expected. Opportunities to also engage in wet lab work will be available. We have developed approaches to simulate self-assembly of the SNARE complex components in asymmetric membranes with physiological lipid composition and applied these approaches to provide a molecular movie of the formation of a fusion pore by an arrangement of SNARE complexes. The person joining this project will proceed to a more complex step including the accessory proteins complexin, synaptotagmin, Munc-18 and Munc-13, which regulate the function of the SNARE complexes. The ultimate goal is to generate a molecular movie from the activating step of Ca2+ binding to fusion pore formation.

  • Conducts research on specific areas of study as assigned.

  • Prepares research reports and technical papers for publishing.

  • Investigates the feasibility of applying a wide variety of scientific principles and theories.

  • Maintains substantial knowledge of state-of-the-art principles and theories.

  • Develops advanced analytical models and systems and provides solutions and analyses to support strategic and tactical decisions.

  • Adheres to University and unit-level policies and procedures and safeguards University assets.

This list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include other duties or responsibilities as necessary.


  • Ph.D. in relevant field

  • No prior experience required

  • Ability to recognize, analyze, and solve a variety of problems.

  • MD simulations using GROMACS

  • Conversion of protein complex pdb structures to coarse grained models

  • Coarse grained simulations using MARTINI force field

  • Atomistic simulations using GROMOS96

  • Simulations of membrane self assembly

The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University Of Miami Miller School Of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.

The University of Miami is an Equal Opportunity Employer - Females/Minorities/Protected Veterans/Individuals with Disabilities are encouraged to apply. Applicants and employees are protected from discrimination based on certain categories protected by Federal law. Click here for additional information.

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