Research Associate - Term

Date Posted: 10/25/2021
Req ID: 19068
Faculty/Division: Temerty Faculty of Medicine
Department: Department of Molecular Genetics
Campus: St. George (Downtown Toronto)

Description:

OVERVIEW:

The Department of Molecular Genetics in the Faculty of Medicine, University of Toronto invites applications for the position of Research Associate (Limited Term) to lead/design research projects in the area of antifungal drug resistance and antifungal drug development. The core project is a partnership with Bright Angel Therapeutics, a company focused on the development of novel therapeutics for the treatment of drug-resistant and life-threatening fungal infections.

ESEENTIAL QUALIFICATIONS:

Candidates require a Ph.D. and postdoctoral experience with demonstrated academic and research expertise in the field of microbiology, molecular biology, and antifungal drug discovery. 7 years of post-doctoral experience in antimicrobial drug discovery. The incumbent will lead and conduct research pertaining to projects in the lab focused on discovery and development of novel antifungals. Experience working with Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, and antifungal drug resistance is a strong asset. Candidates must have demonstrated experience with antifungal susceptibility testing, mammalian cell culture, cytotoxicity testing, microscopy, chemical genetic analyses to identify the compound targets, and biochemical assays of target engagement. Candidates will have experience preparing manuscripts for submission to peer review publications/journals, and assisting with preparing research proposals to be submitted to granting agencies. Must have experience presenting findings at team meetings and conferences. Candidates must have experience designing, planning, and executing experiments and research. Strong organizational, interpersonal, and communication skills is required, and candidate must be able to work positively with others in a large multi-collaborative laboratory.

YOUR RESPONSBILITIES WILL INCLUDE:

• Designing, planning and executing research projects.
• Leading the whole cell antifungal activity testing and mammalian cytotoxicity testing of candidate antifungal compounds.
• Contributing directly to research programs focused on identifying the targets of antifungal compounds. Relevant assays include chemical genomic profiling involving genome and barcode sequencing, mutant construction and phenotypic characterization, and fluorescence polarization assays of ligand binding to targets with lysates and purified proteins.
• Contributing to research programs focused on dissecting mechanisms of fungal drug resistance,. Relevant assays include but are not limited to: cloning, PCR, qRT-PCR, electrophoretic analysis, protein and enzyme assays, microbial transformations, drug resistance testing, replicating yeast mutant libraries, and monitoring compound intracellular accumulation.
• Reading published papers relevant to the experiments being performed and adapting procedures accordingly.
• Liaising with collaborators and industry partners and assisting in the compilation, analysis and reporting of research findings.
• Preparing manuscripts for submission to peer review publications/journals when relevant.
• Presenting findings at local, national and international conferences when relevant.
• Assisting with research proposals to be submitted to granting agencies.
• Assisting with general laboratory biosafety and maintenance, including inventories, equipment repair, ordering, and shipping reagents.

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas.

All qualified incumbents are encouraged to apply; however, Canadians and permanent residents will be given priority.

This is a one year limited term research associate position

Closing Date: 02/28/2022,11:59PM ET
Employee Group: Research Associate
Appointment Type: Grant - Term
Schedule: Full-Time
Pay Scale Group & Hiring Zone: R01 -- Research Associates (Limited Term): $46,819 - $87,785
Job Category: Research Administration & Teaching

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All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.

Diversity Statement
The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ2S+ persons, and others who may contribute to the further diversification of ideas.

As part of your application, you will be asked to complete a brief Diversity Survey. This survey is voluntary. Any information directly related to you is confidential and cannot be accessed by search committees or human resources staff. Results will be aggregated for institutional planning purposes. For more information, please see http://uoft.me/UP.

Accessibility Statement
The University strives to be an equitable and inclusive community, and proactively seeks to increase diversity among its community members. Our values regarding equity and diversity are linked with our unwavering commitment to excellence in the pursuit of our academic mission.

The University is committed to the principles of the Accessibility for Ontarians with Disabilities Act (AODA). As such, we strive to make our recruitment, assessment and selection processes as accessible as possible and provide accommodations as required for applicants with disabilities.

If you require any accommodations at any point during the application and hiring process, please contact uoft.careers@utoronto.ca.
All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.

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