Research Associate Position, Infectious Diseases Division

Employer
University of Pennsylvania
Location
Philadelphia, PA

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Administrative Jobs
Academic Affairs, Research Staff & Technicians
Employment Type
Full Time
Institution Type
Four-Year Institution

Job Details

Research Associate Position, Infectious Diseases Division

Location:
Philadelphia, PA
Open Date:
Sep 24, 2021
Close Date:
Sep 24, 2023
Description:

The Division of Infectious Diseases in the Department of Medicine at the Perelman School of Medicine at the University of Pennsylvania seeks candidates for a Research Associate position in the Academic Support Staff. This appointment will be initially for one (1) year and continuation during that time period and renewal is based on satisfactory performance and availability of funding (limited to three (3) years). Expertise is required in the specific area of in vitro transcription, design, and production of nucleoside-modified mRNA, immunogen design, lipid nanoparticles (LNPs) formulation, LNP characterization, and targeting of LNPs to specific cell types and tissues. Applicants must have a Ph.D. with a minimum of 3 years of experience in mRNA design, mRNA production, formulation into LNPs, and in vivo assessment of mRNA based vaccines against both viral and bacterial pathogens, multiparametric flow cytometry (i.e. >16 colors), and assessment of innate immune responses and antigen specific T and B cells. Experience with mRNA-LNP bioditribution (i.e. organ and cell levels) is highly preferred.  Selected candidates will be expected to present research findings at peer academic institutions as well as national and international scientific meetings under the supervision and training of Dr. Drew Weissman. Qualified individuals will exhibit creativity in the application of cutting-edge techniques and approaches to advance their scientific progress. 

Responsibilities may include design, produce and purify (i.e. HPLC, cellulose) nucleoside modified mRNA; optimize in vitro transcription reactions; automate the production and purification process of mRNA; formulate mRNA into LNP; optimize LNP formulation for efficient in vivo delivery of mRNA; modify LNP surface using different chemistries for organ and cell type targeting; design and conduct multicolor flow cytometry experiments (>16 colors) to assess mRNA bio distribution and cell specific uptake of LNP and targeted LNPs; designs and conduct vaccine experiments; assess antigen specific T cell, antigen specific B cells antigen specific Tfh cell/GCB cells and Long lived plasma cells for vaccine performance. Develop neutralization assays. Perform molecular biology techniques such as cloning, nucleic acid extraction, qPCR, and RNA sequencing. Use of basic and advanced techniques to define correlates of mRNA delivery, and efficacy. Writing of standard operating procedures, and reports. Managing collaborations, train personnel, and supervise a team of 2-5 people.

Successful applicants will have an opportunity to interact and collaborate with different research faculty operating from the University of Pennsylvania, affiliated institutions, and outside collaborators. Use cutting-edge techniques to advance their research and attend both national and international conferences. Opportunities to attend/enroll in internal faculty development courses (i.e. leadership, scientific management, diversity and inclusion), attend/enroll in courses at the University of Pennsylvania, and apply to intra and extramural grants may also be available. The candidate is expected to secure at least one grant as a co-PI during employment.

We seek candidates who embrace and reflect diversity in the broadest sense. The University of Pennsylvania is an EOE. Minorities/women/individuals with disabilities/protected veterans are encouraged to apply.

Organization

Welcome to the University of Pennsylvania! Penn is the largest private employer in Philadelphia and is a world-renowned leader in education, research, and innovation.  

Across our 12 highly-regarded schools, more than 25,000 students, and more than 4,000 faculty members, we become one university: a wide-ranging, ever-changing community that draws its strength from a multitude of races, ethnicities, genders, sexual orientations, historical traditions, ages, religions, disabilities, veteran status, interests, perspectives, and socioeconomic backgrounds. 

Penn carries on the principles and spirit of its founder, Benjamin Franklin: entrepreneurship, innovation, invention, outreach, and a pragmatic love of knowledge. Franklin's practical outlook has remained a driving force in the university's development. To learn more, visit About Penn

Vision

 

As engines of knowledge and new ideas, universities have the unique potential to define the future rather than be defined by it; to pioneer change rather than merely manage it. To do so requires a plan both visionary and pragmatic. The Penn Compact 2022 motivates community members to innovate, be radically inclusive, and positively impact their local, national, and global communities. 

 

Penn’s fundamental priorities — increasing access, integrating knowledge and engaging locally, nationally and globally — are supported by the three core values that make us uniquely Penn: inclusion, innovation, and impact. 

 

Learn about the signature initiatives of the Penn Compact 2022:  

 

Diversity 

 

Understanding and appreciating diversity is one of Penn's most important priorities and is fundamental to success in today's world. 

 

Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class. 

 

To learn more about Diversity and Inclusion at Penn visit: 

 

Benefits 

 

Penn offers a wide range of benefits and perks - from Penn's retirement Matching Plan to bike repair stations to access to the full LinkedIn Learning library to adoption assistance to workshops at the letterpress and book arts studio and much more! 

 

Campus and Beyond

 

We invite you to explore our campus and its stately buildings and state-of-the-art facilities. 

 

Try our self-guided tour! Come and visit

 

Learn about sustainability at Penn

 

News 

 

Stay up-to-date with Penn's response to COVID-19: Coronavirus Information & Resources

 

Penn supports news publications that tell the ongoing story of the University community, communications services for external media, telephone and video services, and other media resources: Campus Media 

 

Connect with us!  

 

Instagram: @uofpenn 

Twitter: @Penn 

 

 

Find Us
Telephone
(215) 898-7372
Location
3451 Walnut Street
Philadelphia
PA
19104
United States

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