Life Science Research Professional
School of Medicine, Stanford, California, United States
Stanford University Department of Medicine, Division of Cardiovascular Medicine
is seeking a Life Science Research Professional 2 (LSRP 2) in the Ashley Lab to perform more complex functions and activities involved in defined research projects, and independently conduct a portion of the research project(s).
The Ashley lab is seeking an LSRP 2 who will use CRISPR-based genome engineering technologies to develop high throughput assays of genotype-phenotype relationships in single cells. The aim of our NIH-funded project is to determine structure-function relationships for key genes associated with hypertrophic cardiomyopathy, a serious inherited disease of heart muscle that can lead to heart failure and sudden cardiac death. The LSRP 2 will work as part of an interdisciplinary team of scientists and physician-scientists whose skills include bioengineering, in vitro genome engineering, and use of patient derived induced-pluripotent stem cell (iPSC) technologies for disease modeling. The project will also involve close collaboration with multiple laboratories in the Departments of Medicine, Genetics and Bioengineering at Stanford and the Department of Chemistry and Chemical Biology at Harvard, groups who have pioneered many of the techniques we use. Candidates with specific prior experience in genetics, genome engineering, iPSC biology and/or cardiac disease modeling will be considered strongly.
Our group is a central part of Stanford's Center for Inherited Cardiovascular Disease. We are focused on the role of the human genome in health and disease and specifically inherited cardiovascular disease. Lab member expertise ranges from computational biology and deep learning to disease modeling at the bench, and extends to clinical applications. This allows us to seamlessly integrate hypotheses generated from large scale human genomic data with mechanistic inquiry required to pursue the underlying causes of identified associations. Duties include:
- Independently conduct a portion of the research project(s). Make recommendations on experimental design and/or research direction to principal investigator.
- Independently conduct complex (lab and/or field) experiments to gather data for a portion of a major research project.
- Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols.
- Develop new research protocols where appropriate protocols are not described in the literature or where modification or adaptation of standard procedures and protocols is required.
- Participate in multidisciplinary teams across different faculties or schools.
- Perform ongoing literature review to remain current with new procedures and related research; apply to ongoing research and development of new protocols.
- Contribute substantively to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.
- Oversee supply and equipment budget under supervision of principal investigator or business manager.
- Work with health and safety department to ensure lab complies with regulations and all required trainings.
- Supervise (either formally or informally) staff or students as needed, including oversight and direction on techniques, as well as consultation on project work. Serve as a technical resource for other research staff.
- Oversee the daily activities of the laboratory including lab maintenance; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
*- The job duties listed are typical examples of work performed by positions in this job classification and are not designed to contain or be interpreted as a comprehensive inventory of all duties, tasks, and responsibilities. Specific duties and responsibilities may vary depending on department or program needs without changing the general nature and scope of the job or level of responsibility. Employees may also perform other duties as assigned. DESIRED QUALIFICATIONS:
EDUCATION & EXPERIENCE (REQUIRED):
- Master's Degree or higher level degree preferred in addition to 1 year of relevant experience.
- Proficiency in mouse colony management including breeding and genotyping.
- English proficiency in scientific writing.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
- Bachelor's degree in related scientific field and two years of relevant work experience; or Master's degree in a related scientific field.
- Comprehensive understanding of scientific principles.
- General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
- Strong analytical skills and excellent judgment.
- Ability to maintain detailed records of experiments and outcomes.
- Ability to work under deadlines with general guidance is essential.
- Excellent organizational skills and demonstrated ability to accurately complete detailed work.
- Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
- Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
- Ability to work in a dusty, dirty, and odorous environment.
- Position may require repetitive motion.
*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.WORKING CONDITIONS:
- May require working in close proximity to blood borne pathogens.
- May require work in an environment where animals are used for teaching and research.
- Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
- Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
- May require extended or unusual work hours based on research requirements and business needs.
Why Stanford is for You:
- Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
- Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
- Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, https://adminguide.stanford.edu.
Imagine a world without search engines or social platforms. Consider lives saved through first-ever organ transplants and research to cure illnesses. Stanford University has revolutionized the way we live and enrich the world. Supporting this mission is our diverse and dedicated 17,000 staff. We seek talent driven to impact the future of our legacy. Our culture and unique perks
empower you with:
- Freedom to grow. We offer career development programs, tuition reimbursement, or audit a course. Join a TedTalk, film screening, or listen to a renowned author or global leader speak.
- A caring culture. We provide superb retirement plans, generous time-off, and family care resources.
- A healthier you. Climb our rock wall, or choose from hundreds of health or fitness classes at our world-class exercise facilities. We also provide excellent health care benefits.
- Discovery and fun. Stroll through historic sculptures, trails, and museums.
- Enviable resources. Enjoy free commuter programs, ridesharing incentives, discounts and more.
*- Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.
To be considered for this position please visit our web site and apply on line at the following link: stanfordcareers.stanford.edu
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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