Research Assistant 3
- Employer
- Case Western Reserve University
- Location
- Case Main Campus
View more
- Administrative Jobs
- Academic Affairs, Research Staff & Technicians
- Employment Type
- Full Time
- Institution Type
- Four-Year Institution
Job Details
Location: Case Main Campus
Regular/Temporary: Regular
Full/Part Time: Full-Time
Job ID: 8935
Job Description
Position ObjectiveWorking under limited supervision, the Research Assistant 3 will carry out complex research assignments and perform experiments on projects related to cardiac contractile function. The research assistant will work closely with other lab members and focus on research involving molecular biology of cardiac muscle contraction. This position will perform a wide array of cellular and molecular biology experiments using gel electrophoresis, protein biochemistry, western blots, bacterial transformation and culture and other in vitro techniques. The research assistant will use various molecular and computational methods to bridge the gap of understanding between structure and experimental observations in cardiac muscle physiology. Essential Functions
- Work closely with the principal investigator to carry out research projects that characterize the roles of myofilament contractile proteins in the regulation of cardiac muscle contraction. (6%) Coordinate research activities and conduct general molecular biology, including design and implement cloning strategies, PCR, mutagenesis, gel electrophoresis, gel purification, plasmid preparation, bacterial transformation, protein biochemistry, bacterial culture, western blotting and expression and purification of recombinant proteins. (25%)Devise new protocols and techniques for protein purification and protein binding studies that involve a high degree of skill and training. Carry out complex experiments to characterize binding properties of recombinant contractile proteins with various ligands using a variety of molecular and biochemical methods, including but limited to co-sedimentation assays, isothermal calorimetry, NMR, etc. (45%)Evaluate adequacy of biochemical techniques, study and test new procedures. Collect and analyze data, provide feedback on experimental design. Prepare and present research results in lab meetings. Maintain lab records. (14%) Assist in manuscript preparation and editing. May co-author research projects. (6%)
- May supervise students and technicians. (1%)Monitor laboratory budget. Oversee inventory and standard operating procedures. Maintain equipment, prepare buffer/media/reagents and dispose biohazardous waste. (2%) Perform other duties as assigned. (1%)
- Knowledge of commonly used concepts, practices and procedures in chemistry, physics, biochemistry and molecular/cellular biology and in vivo cardiovascular function. Ability to perform various molecular biology techniques. Prior experience with cell culture and protein expression/purification.Experience with computer programming and molecular dynamic simulation preferred.Ability to follow instructions and pre-established guidelines to perform the functions of the job with minimal supervision.Strong organization skills and maintenance of a laboratory notebook with attention to scientific detail.Ability to multi-task, prioritize and give attention to detail in order to complete tasks and meet deadlines.Ability to effectively operate basic molecular and cellular biology laboratory equipment. Ability to problem-solve effectively and assist in the development and implementation of alternative solutions as needed. Must demonstrate good judgment and logical decision-making.Ability to work effectively, both independently and collaboratively within a team.Ability to learn and apply new techniques, ideas, processes, policies, functions, etc. Must be highly motivated and a self-starter.Ability to conform to shifting priorities, demands and timelines. Must be flexible in order to respond to project adjustments and alterations promptly and efficiently. Must be able to adapt to varying workloads and respond appropriately to stressful situations.Excellent verbal and written communication skills; good interpersonal skills with the ability to interact with colleagues and supervisors face to face.Ability to follow through on assigned projects and provide timely follow-up as needed.Ability to meet consistent attendance.
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In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
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Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
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Case Western Reserve University has implemented a COVID Vaccination policy requiring evidence of COVID-19 vaccination for all students, faculty and staff with an on-campus presence. Religious and medical exemptions may be provided in accordance with applicable federal and state laws. For more information go to: https://case.edu/equity/covid-19-accommodations. Applicants may contact the Office of Equity at 216-368-3066 /equity@case.edu for information regarding religious or medical exemptions as an accommodation.
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Organization
Working at Case Western Reserve University
Case Western Reserve University is among the nation's leading research institutions. Founded in 1826 and shaped by the unique merger of the Case Institute of Technology and Western Reserve University, Case Western Reserve is distinguished by its strengths in education, research, service and experiential learning. Located in Cleveland's University Circle, we offer nationally recognized programs in the arts and sciences, dental medicine, engineering, law, management, medicine, nursing and social sciences.
Student enrollment exceeds 9,800 students, forty percent of whom are undergraduates. Facultyand students hail from more than 90 countries, with academic interests that reach every region of the world. Case Western Reserve, with the support of individuals, corporations and foundations, aids nearly 100 designated research centers.
As a service-oriented institution dedicated to civic leadership, Case Western Reserve seeks individually and collectively to prepare our students to improve the human condition and to direct the benefits of discovery toward a better society. This effort is not limited to the university's classrooms, laboratories, libraries, residence halls and athletic fields, but includes partnerships with many other institutions. We build these partnerships believing that our ability to improve the human condition should begin in our own community.
Case Western Reserve University remains Ohio's top-ranked school among the nation's premier national universities, as ranked by U.S. News & World Report and is the only Ohio institution ranked in the top 50 nationally. We promote a culture of inquiry marked by rigor, creativity, curiosity, innovation, respect, sensitivity and open communication of ideas.
The university supports interdisciplinary partnerships in education and research with numerous faculty holding joint appointments in more than one Case Western Reserve school or department, as well as at neighboring institutions. These relationships launched many of the unique pairings of science, business and liberal arts into the centers and programs that enhance the undergraduate and graduate experience at the university. Our dual degree programs enrich the educational experience for those students who choose to balance the technical requirements of engineering or the sciences with a strong interest in the humanities.
With more than $375 million in research funding annually, the university attracts outstanding undergraduate and graduate students along with renowned faculty whose research has made significant contributions to the way we live and work. Case Western Reserve counts 15 Nobel laureates among our alumni and current and former faculty, including the first American scientist to ever receive the prize.
Our students' experiences in cultural institutions, clinics, social service agencies and industry are not viewed as “extra-curricular,” but create the learning experience that defines a Case Western Reserve education. The university's service programs in the Cleveland Municipal School District have impacted more than 145,000 students with more than 43 signature programs. The university has launched more than 580 community partnerships on the local, national and international levels. Annually the university sponsors Case for Community Day, an event where hundreds of Case Western Reserve employees and students lend their time and talent to targeted community development projects in the Greater Cleveland area.
Our alumni number more than 110,000 and constitute a “who's who” of every profession. Alumni represent one of the university's strongest resources, playing a vital role in campus life through their work as advisors, mentors, friends and advocates.
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