LAB RESEARCH ANALYST II

Employer
Duke University
Location
B&B - GCB Shared Resources
Closing date
Oct 22, 2021

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Administrative Jobs
Academic Affairs, Research Staff & Technicians

Job Details

School of Medicine:

Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.

Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

Lab Research Analyst II (LRA II)

Position Description:

Occupational Summary:

The Duke University School of Medicine is seeking a Laboratory Research Analyst II for the Duke Proteomics and Metabolomics Core Facility (https://genome.duke.edu/cores-and-services/proteomics-and-metabolomics). The Core Facility is currently staffed with ten scientists (five PhDs, four of whom are Research Professors in the School of Medicine) with a combined 160+ years’ experience in the analysis of peptides, proteins, and small molecules. The Facility is equipped with ~$10M in dedicated LC-MS/MS hardware and software, and it is located in a custom-built (2017) 8,100 sq. ft. laboratory. Seeking a self-starting scientist with good problem-solving skills and strengths in quantitative analysis, particularly by LC-MS/MS. Job duties will be to work in a fast-paced, team-based environment to conduct a variety of complex and independent investigations addressing physical, chemical, and other research laboratory experiments to obtain and interpret data for research projects at Duke, specifically addressing metabolomics and proteomics in cancer, neurodegenerative diseases, and infectious diseases. Scientific integrity, curiosity, and determination are key qualities of a successful candidate.

In particular, the Lab Research Analyst II will conduct a variety of complex laboratory procedures and specialized laboratory techniques for the analysis of endogenous metabolites, drug molecules, peptides and proteins in the Proteomics and Metabolomics Core Facility for the School of Medicine. Note that both SOP-driven and independent analyses will be required, and proven analytical thinking and problem-solving skills are critical. The ability to effectively work in a multidisciplinary team environment and move easily from one task to another is essential.

Tasks may include:

1) 40% - Preparation of biological samples for metabolomic, proteomic, and pharmacokinetic analyses.

2) 30% - Quantification of metabolites using triple quadrupole mass spectrometry, and contribution to the development of new LC-MS/MS assays. Validation of figures of merit for quantitative LC-MS/MS assay.

3) 10% - Protein identification and quantitation using nanoscale capillary liquid chromatography and analytical scale liquid chromatography coupled with either high resolution, accurate mass tandem mass spectrometers (LC/MS/MS) or triple quadrupole mass spectrometers operated in MRM mode.

4) 15% - Contribution to written reports and publications of results in collaboration with investigators inside and outside of Duke. Review journals, abstracts, and scientific literature to keep abreast of new developments and to obtain information regarding previous experiments to aid in the design and development of original procedures and techniques.

5) 5% - Presentation of their ongoing work at group meetings and national meetings, and critical evaluation of new approaches for metabolomics and proteomics presented in the literature or by others.

Education/Training:

Work requires a bachelor's degree in chemistry, biochemistry, biology or other directly related scientific field, plus four years’ experience. A related master's degree or PhD may offset required years of experience on a 1:1 basis, e.g., a two-year master's degree in lieu of two years of experience.

Experimental design/planning, sample preparation, LC-MS/MS sample analysis and results interpretation skills are essential. Additional skills in statistics, bioinformatics, or programming are a plus.

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

Organization

Read our Diversity Profile History

Duke University was created in 1924 by James Buchanan Duke as a memorial to his father, Washington Duke. The Dukes, a Durham family that built a worldwide financial empire in the manufacture of tobacco products and developed electricity production in the Carolinas, long had been interested in Trinity College. Trinity traced its roots to 1838 in nearby Randolph County when local Methodist and Quaker communities opened Union Institute. The school, then named Trinity College, moved to Durham in 1892, where Benjamin Newton Duke served as a primary benefactor and link with the Duke family until his death in 1929. In December 1924, the provisions of indenture by Benjamin’s brother, James B. Duke, created the family philanthropic foundation, The Duke Endowment, which provided for the expansion of Trinity College into Duke University.Duke Campus

As a result of the Duke gift, Trinity underwent both physical and academic expansion. The original Durham campus became known as East Campus when it was rebuilt in stately Georgian architecture. West Campus, Gothic in style and dominated by the soaring 210-foot tower of Duke Chapel, opened in 1930. East Campus served as home of the Woman's College of Duke University until 1972, when the men's and women's undergraduate colleges merged. Both men and women undergraduates now enroll in either the Trinity College of Arts & Sciences or the Pratt School of Engineering. In 1995, East Campus became the home for all first-year students.

Duke maintains a historic affiliation with the United Methodist Church.

Home of the Blue Devils, Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world.

Mission Statement

Duke Science"James B. Duke's founding Indenture of Duke University directed the members of the University to 'provide real leadership in the educational world' by choosing individuals of 'outstanding character, ability, and vision' to serve as its officers, trustees and faculty; by carefully selecting students of 'character, determination and application;' and by pursuing those areas of teaching and scholarship that would 'most help to develop our resources, increase our wisdom, and promote human happiness.'

“To these ends, the mission of Duke University is to provide a superior liberal education to undergraduate students, attending not only to their intellectual growth but also to their development as adults committed to high ethical standards and full participation as leaders in their communities; to prepare future members of the learned professions for lives of skilled and ethical service by providing excellent graduate and professional education; to advance the frontiers of knowledge and contribute boldly to the international community of scholarship; to promote an intellectual environment built on a commitment to free and open inquiry; to help those who suffer, cure disease, and promote health, through sophisticated medical research and thoughtful patient care; to provide wide ranging educational opportunities, on and beyond our campuses, for traditional students, active professionals and life-long learners using the power of information technologies; and to promote a deep appreciation for the range of human difference and potential, a sense of the obligations and rewards of citizenship, and a commitment to learning, freedom and truth.Duke Meeting

 “By pursuing these objectives with vision and integrity, Duke University seeks to engage the mind, elevate the spirit, and stimulate the best effort of all who are associated with the University; to contribute in diverse ways to the local community, the state, the nation and the world; and to attain and maintain a place of real leadership in all that we do.”

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