Research Assistant 4

Job description

Job Title: Research Assistant 4
Location: Case Main Campus
Regular/Temporary: Regular
Full/Part Time: Full-Time
Job ID: 8905

Working with a high degree of independence and under general direction, the Research Assistant 4 will coordinate work in metabolomics, chromatography, and mass spectrometry. The research assistant 4 will work with the Mass Spectrometry Scientist. This will include the daily management and operation of the latest liquid chromatography instrumentation (Agilent 1260 HPLC, Vanquish UHPLC), and operation of Thermo Orbitrap systems, including an Orbitrap Eclipse Tribrid Fusion MS and an Orbitrap Exploris 240 mass spectrometer. The research program is interested on understanding how the microbiome contributes to human health and susceptibility to infectious disease. The research team collaborates with international partners in Arica, Europe, and Canada.


    Coordinate laboratory/ research activities with technicians and post-doctoral scholars. Organize experiments and the preparation of samples for metabolite and mass spectrometry analysis. Maintain experimental records on all activities, protocols, data, etc. Ensure laboratory safety. (30%)Perform the most complex quantitative analytical procedures of a non-routine nature integrating liquid chromatography and mass spectrometry-based tools (metabolomics, proteomics) to study host-microbial interactions in human health. Operate and manage liquid chromatography systems related to metabolomics and proteomics experiments. Execute, analyse, and deliver on assigned research projects. (20%) Assist in developing new protocols and techniques for research projects involving a high degree of skill and training. This could include developing/adapting metabolomic/proteomic sample processing protocols for different biological samples, test and optimize workflows for metabolomic/proteomic analysis, etc. (10%) Co-author research projects. Participate in manuscript and grant writing, co-author research projects and independently write sponsor progress reports, manuscripts, grant and pilot applications. (10%) Set up apparatus and perform a wide variety of equipment and standardized procedures. Oversee/maintain inventory, equipment, and facilities, and recommend purchases. Responsible for environmental safely rules and handling biohazard waste. (10%)


    Teach or instruct others in research techniques. Instruct students, technicians, and post-docs in methodologies, acquisition, and preparation of samples for proteomic/metabolomic analysis. Evaluate adequacy of techniques; study and test new procedures and analyzes data. This could include processing of samples for new experiments, handling data processing and performing data analysis in coordination with Bioinformatics lead. Perform analysis of data from proteomics experiments. (5%)Supervise students and technicians in standard laboratory policies as well as metabolomic, proteomic, and liquid chromatography research techniques. (5%)Provide input and recommendation to principal investigator to optimize and troubleshoot procedures to comply with expected outcomes. (5%) Participate in weekly research meetings and conferences to present data. May co-author research projects. (3%)Perform other duties as assigned. (2%)


Department: Frequent contact with principal investigator for project and lab communication, infrequent contact with department administration.

University: Frequent contact with other university collaborating departments including other basic science departments regarding on-going projects and lab activities.

External: Infrequent contact with vendors, IRB, other collaborating institutions.

Technical, students: Daily contact with students and technicians to explain data, techniques, etc., and to maintain workflow.


Supervise students, post docs, and technicians


Experience: 5 to 8 years of related experience required.

Education/Licensing: Bachelor’s degree required; preferably in Chemistry, Physics, Biotechnology, or related field.


    Has knowledge of commonly used concepts, practices, and procedures within metabolomics, chemistry, biochemistry, or related discipline. Ability to rely on instructions and pre-established guidelines to perform the functions of the job. Ability to operate laboratory equipment including advanced liquid chromatography systems, Thermo Orbitrap Mass Spectrometers for metabolomics/proteomics Ability to ensure laboratory safety.Ability to perform basic laboratory assays. Must be highly motivated, responsible, dependable and a self-starter. Ability to meet consistent attendance. Good/strong organization skills: ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Ability to work with sensitive information and maintain confidentiality. Excellent customer service skills: ability to maintain effective working relationships and address the potential and current needs of customers. Ability to work effectively independently and collaboratively within a team. Ability to interact with colleagues, supervisors, and customers face to face. Effective problem-solving skills; must demonstrate sound judgment and good decision-making.


The employee will work mostly in Biosafety Level 2 (BSL-2) facilities and will use infectious materials, and general chemicals. This job will include handling of human biological specimens that may be infected with HIV, malaria, TB, and other pathogens. This position may provide opportunities for international travel and presentations at international conferences.

Diversity Statement

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.


Reasonable Accommodations

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.





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Job No:
Posted: 6/10/2021
Application Due: 9/8/2021
Work Type: Full Time