School of Medicine:
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Postdoctoral Associate Position
A mouse model of Sturge Weber Syndrome to investigate disease pathobiology
Laboratory of Douglas A. Marchuk, Ph.D.
Department of Molecular Genetics and Microbiology
Duke University Medical Center
A post-doctoral position is available to investigate the pathobiology of Sturge-Weber Syndrome (SWS), a rare vascular disorder characterized by vascular lesions involving dermal facial capillaries, the leptomeninges, and vessels in the eye. Our collaborative group determined that the cause of SWS is a somatic, mosaic, activating mutation in the GNAQ gene, encoding the G protein subunit alpha q (see PMID: 23656586). We have now generated an engineered mouse strain that expresses the wild-type GNAQ transcript, but upon Cre recombination, switches to express the mutant transcript. The goal of this project is to utilize this mouse to generate a robust mouse model of the disease, and using this tool, investigate the molecular mechanisms of vascular malformation development and growth.
Requirements: The position requires cellular and molecular biology skills, and especially, a strong background in mouse genetics and/or mouse models of disease. The ideal candidate will enjoy working in a fast-paced, rigorous, scientific environment, be adept at multi-tasking, and be able to work both independently and in a collaborative team environment. The candidate must have excellent verbal and written communication skills. A recent PhD is preferred (less than 3 years of research experience after receipt of the doctoral degree). This 100% grant funded position will be one year to start with extensions contingent on continued funding, performance, and needs of the lab.
DEFINITION: The Postdoctoral Appointee holds a PhD or equivalent doctorate (e.g. ScD, MD, DVM). Candidates with non-US degrees may be required to provide proof of degree equivalency.1. A candidate may also be appointed to a postdoctoral position if the candidate has completed all of the requirements for a degree but the degree has not been formally conferred: in this case, the candidate may present evidence of completion of the degree requirements, together with a statement documenting the date on which the degree is to be conferred. If the degree is not conferred by this projected date, the postdoctoral appointment may be terminated.2. Note for international candidates: Generally, immigration classifications (e.g., H-1B, J-1, etc.) require that the requisite degree be conferred before a petition can be filed or a visa document issued to sponsor the individual.
The term of the appointment is limited (see Section 5 of the Postdoc Policy for length of appointment). The appointment involves substantially full-time research or scholarship, and may include teaching responsibilities. The appointment is generally preparatory for a full time academic or research career. The appointment is not part of a clinical training program, unless research training under the supervision of a senior mentor is the primary purpose of the appointment.
The Postdoctoral Appointee functions under the supervision of a mentor or a department at Duke University. The Postdoctoral Appointee is expected to publish the results of his or her research or scholarship during the period of the appointment. EXPECTATION: The conscientious discharge of research or scholarship responsibilities, which may include teaching responsibilities for Postdoctoral Associates Conformance to standards of responsible conduct in research Compliance with good scholarly and research practice Maintenance of a laboratory notebook and/or other comparable records of research activity, which remains the property of Duke University upon termination Adherence to University standards regarding use of isotopes, chemicals, infectious agents, animals, human subjects, and the like Open and timely discussion with the mentor regarding all facets of the Postdoctoral Appointee's research activities.
Postdoctoral Appointees are encouraged to consult the AAMC Compact Between Postdoctoral Appointees and Their Mentors for suggested guidelines for the Postdoctoral Appointee-mentor relationship Prompt disclosure to the mentor regarding the possession and desire to distribute materials, reagents, software, copyrightable and potentially patentable discoveries derived from the Postdoctoral Appointee's research. Collegial conduct towards members of the research group and others as described in the Duke University School of Medicine Honor Code of Professional Conduct and other relevant conduct policies pertaining to other schools at Duke University. Compliance with all applicable University and departmental policies and procedures.
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