University of Colorado – School of Medicine
Department of Pathology
Position Number: 00784708
The University of Colorado Denver l Anschutz Medical Campus seeks individuals with demonstrated commitment to creating an inclusive learning and working environment. We value the ability to engage effectively with students, faculty and staff of diverse backgrounds.Nature of WorkInstructor position available for highly independent PhD scientist, with at least 5 years of postdoctoral experience in the area of brain metastasis research, to join the laboratory of Diana Cittelly PhD, at the Department of Pathology, School of Medicine, University of Colorado Anschutz Medical Campus (Aurora, CO, USA). Our goal is to unveil the mechanisms that allow cancer cells to spread to and colonize the brain and to discover novel therapeutic strategies for brain metastases. Ongoing projects include 1) defining estrogen function in early extravasation and blood-brain-barrier dysfunction during metastasis, 2) defining estrogen function in microglia recruitment and polarization during brain metastatic colonization, 3) identifying novel targetable markers for established brain metastases in breast cancer. To achieve our goal, we use a variety of neuroscience, molecular biology, cell and tissue imaging and in vivo modeling of metastasis. The instructor in the position should have demonstrated experience in tissue culture of primary glial and neuronal cells, basic IF, IHC imaging and confocal microscopy, organotypic brain slices, co-culture systems, radiation and glial biology, modeling of invasion, tumor-initiation assays for cancer cells. This is a fast paced field that will give you ample opportunity for innovation, development of advanced technical skills and highly translational research. As such, Instructor will demonstrate desire to learn, ability to multitask, superb organizational skills and a big dose of self-motivation. We work in close collaboration with neurosurgeons and oncologists so we are looking for a team-member who enjoys communication with people from diverse backgrounds and is aware of the value placed on their hands when handling human tissue. The instructor is expected to be the driving force in their own project, be self-motivated and be a critical thinker. Instructors are also expected to write grants and manuscripts, and present at scientific conferences. Additionally, it is expected that the instructor in this position will supervise and train graduate students and junior postdocs in the Cittelly Lab. ___________________________________________________________________________Job Description/Duties:Primary activities in the lab include -but are not limited to:
- Performing preclinical studies with brain metastasis patient-derived cancer cells and cancer cell lines. Isolation and characterization of cancer and brain cell populations from clinical samples and mice, tissue labeling and imaging. In vitro cell culture and cell-based assays, standard molecular and biochemistry techniques.Lead the management and organization of the Cittelly LabAble to work independently Train and supervise graduate students, junior postdocsDevelop new areas of investigation, perform preliminary experiments to support grants (both as co-investigator in the PI’s grant, as well as own grants). Prepare grants as a PI as appropriate. Write manuscripts, and present at scientific conferences.
- PhD degree, with 5 years of postdoctoral experience in the area of brain metastasis research.
Job Category: Faculty
Primary Location: Aurora
Posting Date: Jun 4, 2021
Unposting Date: Ongoing