Core Research Facility Manager
Job no: 516918
Work type: Staff Full-Time
Location: In the State of Florida
Department:29080100 - MD-PATHOLOGY-GENERAL
Core Research Facility ManagerJob Description:
The Department of Pathology, Immunology and Laboratory Medicine and the University of Florida Diabetes Institute (UFDI) is searching for a candidate to both oversee and operate the UFDI Autoantibody Screening and Serology Core. The UFDI currently operates several research programs that depend on standardized type 1 diabetes (T1D) assays and experiments that are required to screen human and animal blood and tissue samples before they can be used for research. We are searching for an individual with extensive expertise and experience in T1D autoantibody screening procedures as well as serology screening and immunoassay development. This candidate must have experience in ELISA manufacturing, processing, QC, and analysis. In addition, multiplexed immunoassays, human and animal blood and tissue acquisition and processing, luminometry, radiometric immune assays, in addition to computing and statistical analysis skills are required. The candidate must have experience managing and operating immunoassay instrumentation in a core setting. This candidate will interface with faculty, post-docs, staff, students and other academic and industry professionals, and will supervise other staff in this role.
- Autoantibody Screening and Serology Core operations manager, including assay development, processing, and analysis for entities such as the Network for pancreatic Organ Donors with Diabetes (nPOD), the Helmsley Charitable Trust (HCT), and several NIH-funded initiatives, as well as other academic collaborations both internally and externally to UF.
- Maintenance and operation of ELISA instrumentation platforms such as the Spectramax M5 and Accuscan FC, Berthold Centro XS3, and multiplex ELISA instruments such as the Luminex Magpix and MSD Meso QuickPlex platforms.
- Maintain and operate fluidics-based platewashing systems used for serological and immunoassays.
- Train personnel at all levels on the correct use of these instruments. The incumbent must have a track record of customer service in a research serology core setting.
- Display expertise in all software and computational functions for the various instrumentation platforms required for Autoantibody screening and other assays.
- Developing QA and QC pipelines for all experiments and maintain detailed reports for the purpose of submitting to oversight boards fo the various funding authorities.
- Efficient data handling skills to oversee data transfers and backups from all platforms.
- Oversight of an operation that manufactures and ships nPOD and HCT-specific autoantibody screening kits to numerous screening laboratories throughout the United States.
- Ability to troubleshoot issues with all autoantibody, serological, and immunoassay protocols and to develop problem-solving strategies on a case by case basis.
- Must have experience working with Radioimmunoassays in both safely and effectively.
- Responsible for managing a UF EHS radiation control–certified facility and performing daily, weekly, quarterly, and yearly procedures as required by the rules and regulations of UF radiation control.
- Oversee maintenance calls and service agreements for all immunoassay instruments.
- Interface with EHS and other oversight entities at UF to ensure all portions of the autoantibody core meet the required safety specifications.
- Supervisor of the UFDI Autoantibody Screening process for prediction of T1D, a primary component of the Autoantibody Screening and Serology Core, with specific duties including:
- Performs all T1D autoantibody experiments as well QA/QC procedures.
- Coordinate shipping and receiving with multiple national organ procurement organizations.
- Oversee test kit manufacturing to ensure all components meet the requirements.
- Facilitate communication with a multi-national network of test laboratories to ensure their smooth operation and consistent result workflow.
- Ordering and supply chain oversight.
- Training and supervising technical staff in all facets of preparing and performing screening tests.
- Oversee experimental animal procedures as per IACUC protocols. Train staff in animal procedures and techniques.
- Supervise undergraduate students working, researching, or volunteering in the lab. Coordinate schedules and assign tasks to all students.
- Perform human blood processing experiments for the extraction, identification, expression, purification, and isolation of proteins, nucleic acids, tissues, and other cell components. These techniques will include: polymerase chain reaction (PCR and RT-PCR), ELISA, Luminex, RIA, Flow Cytometry, Mononuclear cell enrichment, clinical assays such as HbA1c and CBC, and IHC.
- Serve as laboratory waste manager, chemical inventory manager, and lab safety supervisor. Work with local and federal oversight organizations for laboratory inspections and for consultation on all chemical or biohazardous materials and issues in the lab.
- Collaborate directly with Faculty, research scientists, post-docs, graduate students, technical staff, and undergraduate students on appropriate crossover experiments within the mission of the UFDI.
$68,200 - $70,000Minimum Requirements:
PhD required or more than 10 years science related, core specific advanced training and work experience with at least 5 years in core facility specific applications and at least 3 years of that in research-based technology. Work experience in a multi-user core facility required. Core or technology specific licensure and/or certifications where applicable. Additionally yearly certificate and compliance training if required.Preferred Qualifications:
- Minimum 10 years experience in type 1 diabetes research.
- 5 years of technical core research facility experience.
- Ability to work independently, with initiative, manage time and work with minimal supervision to analyze problems and take appropriate action to complete projects.
- Database management and statistical analysis capabilities.
- Extensive experience with ordering systems and both domestic and international shipping through multiple vendors.
In order to be considered, you must upload your cover letter and resume.
The University of Florida is committed to non-discrimination with respect to race, creed, color, religion, age, disability, sex, sexual orientation, gender identity and expression, marital status, national origin, political opinions or affiliations, genetic information and veteran status in all aspects of employment including recruitment, hiring, promotions, transfers, discipline, terminations, wage and salary administration, benefits, and training.
This is a time limited position.
Application must be submitted by 11:55 p.m. (ET) of the posting end date.Health Assessment Required:
Advertised: 02 Jun 2021 Eastern Daylight Time
Applications close: 16 Jun 2021 Eastern Daylight Time