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Research Assistant 2

Case Western Reserve University
Case Main Campus
Closing date
Jun 28, 2021

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Job Details

Job Title: Research Assistant 2
Location: Case Main Campus
Regular/Temporary: Regular
Full/Part Time: Full-Time
Job ID: 8875

Working under general supervision, the Research Assistant 2 will plan and carry out molecular and cell biology research projects in accordance with general plans. The lab uses functional genomics approaches to elucidate the molecular and cell biology of human epithelia and their dysfunction in disease states such as Cystic Fibrosis. Projects will involve genome editing, gene expression analysis and assays of chromatin accessibility and structure.


    Conduct state-of-the-art genomics technologies and functional assays including but not limited to CRISPR/Cas9 protocols to manipulate cis-regulatory elements in the CFTR locus; analysis of the impact of therapeutic gene editing on CFTR locus architecture and gene expression; analysis of DNA, RNA and proteins; all related protocols of functional genomics including chromatin and RNA purification; analysis by deep sequencing and single cell sequencing and protocols of cell biology and biochemistry such as cell culture and protein analysis. (30%)May assist in developing improved techniques based on genomics technologies and functional assays, projection methods or procedures. (20%) Collect data using appropriate laboratory machines designed for performing cell biological, biochemical and molecular analysis. Data will involve images and numbers, which will be analyzed by appropriate statistical packages. (15%)Maintain certain equipment facilities including laboratory cell culture facility and functional genomics equipment room with advanced thermal cyclers for quantitative gene expression analysis, bioruptors etc. Oversee supply inventory and ordering. Maintain chemical and biological inventories. (10%)Collaborate with faculty members and scientists in training in the performance and analysis of complex and advanced research studies. Train new staff; direct the work of students. (10%)Maintain research related materials to include study data, publications, submitted grants and other scientific documents. Collaborate with scientists in the preparation of manuscripts. Maintain laboratory databases. (8%)


    Participate in meetings to present research study findings. (5%)Perform other duties as assigned. (2%)


Department: Daily contact with principal investigators, postdocs, research associates, research assistants and graduate students to review reagent needs or organize research interactions between different research teams in the department.

University: Daily contact with principal investigators, postdocs, research associates, research assistants, graduate students outside department. The supervisor has many collaborations both internal to the university and elsewhere, which will be facilitated by the research assistant.

External: Limited contact with outside vendors to obtain quotes for reagents, organize maintenance of equipment or solve problems relating to ordering and invoicing.

Students: Daily contact with graduate students, undergraduates and fellows to facilitate their research and ensure an efficient work environment


This position has no direct supervision of staff employees. Train new staff; direct the work of students.


Education and Experience: Bachelor's degree and 1 to 3 years of related experience or Associate's degree in an approved biotechnology program and 2 to 4 years of experience required.


    Prior experience in practical cell biology, genetics, molecular biology or functional genomics techniques and analysis is required, at minimum in undergraduate research setting.Prior bench work experience in an academic science or medicine setting and/or a clinical research setting in strongly preferred.Strong numeracy and data analysis skills. Computer proficiency in Microsoft Suite, Adobe Creative Suite, Graphpad an advantage.Strong oral and written communication skills.Strong organizational and management skills and ability to work in a fast paced environment.Ability to meet consistent attendance.Ability to interact with colleagues, supervisors and customers face to face.


The position entails working in a biomedical research laboratory. The employee will be expected to adhere to all required certification for laboratory work and adhere to all safety regulations including the use of personal protective equipment, standard lab coat, gloves and safety glasses when appropriate. The position may require extended hours including weekends as experiments dictate.

Diversity Statement

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.


Reasonable Accommodations

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.



Working at Case Western Reserve University

Case Western Reserve University is among the nation's leading research institutions. Founded in 1826 and shaped by the unique merger of the Case Institute of Technology and Western Reserve University, Case Western Reserve is distinguished by its strengths in educationresearch, service and experiential learning. Located in Cleveland's University Circle, we offer nationally recognized programs in the arts and sciencesdental medicineengineeringlawmanagementmedicinenursing and social sciences.

Student enrollment exceeds 9,800 students, forty percent of whom are undergraduatesFacultyand students hail from more than 90 countries, with academic interests that reach every region of the world. Case Western Reserve, with the support of individuals, corporations and foundations, aids nearly 100 designated research centers.

As a service-oriented institution dedicated to civic leadership, Case Western Reserve seeks individually and collectively to prepare our students to improve the human condition and to direct the benefits of discovery toward a better society. This effort is not limited to the university's classrooms, laboratories, librariesresidence halls and athletic fields, but includes partnerships with many other institutions. We build these partnerships believing that our ability to improve the human condition should begin in our own community.

Case Western Reserve University remains Ohio's top-ranked school among the nation's premier national universities, as ranked by U.S. News & World Report and is the only Ohio institution ranked in the top 50 nationally. We promote a culture of inquiry marked by rigor, creativity, curiosity, innovation, respect, sensitivity and open communication of ideas.

The university supports interdisciplinary partnerships in education and research with numerous faculty holding joint appointments in more than one Case Western Reserve school or department, as well as at neighboring institutions. These relationships launched many of the unique pairings of science, business and liberal arts into the centers and programs that enhance the undergraduate and graduate experience at the university. Our dual degree programs enrich the educational experience for those students who choose to balance the technical requirements of engineering or the sciences with a strong interest in the humanities.

With more than $375 million in research funding annually, the university attracts outstanding undergraduate and graduate students along with renowned faculty whose research has made significant contributions to the way we live and work. Case Western Reserve counts 15 Nobel laureates among our alumni and current and former faculty, including the first American scientist to ever receive the prize.

Our students' experiences in cultural institutions, clinics, social service agencies and industry are not viewed as “extra-curricular,” but create the learning experience that defines a Case Western Reserve education. The university's service programs in the Cleveland Municipal School District have impacted more than 145,000 students with more than 43 signature programs. The university has launched more than 580 community partnerships on the local, national and international levels. Annually the university sponsors Case for Community Day, an event where hundreds of Case Western Reserve employees and students lend their time and talent to targeted community development projects in the Greater Cleveland area.

Our alumni number more than 110,000 and constitute a “who's who” of every profession. Alumni represent one of the university's strongest resources, playing a vital role in campus life through their work as advisors, mentors, friends and advocates.

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