Post-Doctoral Research Fellow, School of Biological and Chemical Sciences, 67740 Location:
UMKC Volker Campus Full/Part Time:
Full-Time Job ID:
School of Biological and Chemical Sciences, Department of Cell & Molecular Biology & Biochemistry
Position Summary: Professor Ann Smith, in the Department of Cell & Molecular Biology & Biochemistry at the University of Missouri at Kansas City, is seeking applications for a postdoctoral position. Applicants are sought who have an interest in the biochemistry, physiology and pathology of heme and iron metabolism in the context of hemolytic disorders and conditions. The role of the heme-binding protein hemopexin in heme clearance from biological fluids including plasma and cerebrospinal fluid is of particular interest and has important clinical relevance.
Research Program: Hemolysis and the subsequent release of heme from hemoglobin is responsible for the pathologies associated with a wide range of human hemolytic diseases and injuries. Heme drives pathology in part by activating immune system cells to pro-inflammatory states. To deal with this heme toxicity, mammalian cells (predominantly hepatocytes) express hemopexin (HPX), a glycoprotein that avidly binds heme to facilitate its clearance from plasma and from other biological fluids via receptor-mediated endocytosis. The project objectives include continuing investigations on the mechanism(s) of heme clearance by hemopexin for cytoprotection against heme toxicity from hemolysis at the cellular and systemic level. This basic research on hemopexin is needed to improve the clinical therapies for several hemolytic and inflammatory conditions, for example, for plasma protein replenishment therapies. Changes in the levels of hemopexin in biological fluids are potential biomarkers.
This research is multi-disciplinary, and this position is for a scientist with some experience in biochemical techniques including protein chemistry, cell biology (immunofluorescence, microscopy and imaging) and/or CRISPR or siRNA-based functional genomics. It would be beneficial if the candidate already has carried out mammalian cell culture, fluorescence microscopy (including confocal), protein isolation and immunological techniques.
Additional training will be provided as necessary, directed by Professor Ann Smith, who has extensive experience supervising young scientists in the field of heme and iron biology.
Applicants should have a recent doctoral degree in a relevant field including Biochemistry, Molecular Biology and/or Cell Biology and they should have a strong interest in both basic science and biomedical research.
An ability to think critically and creatively, along with strong verbal and written communication skills is essential. Excellent computer skills, organizational and time management skills are also needed. The successful candidate must be able to work independently, as well as in a team environment, and to pay close attention to detail and scientific rigor. They will not only contribute to the development of high-impact research projects by designing and carrying out experiments, and data analyses, but also write manuscripts for publication and grant proposals. Applications for this industry-funded position will be accepted until the position is filled. The University of Missouri is an equal opportunity employer and individuals underrepresented in the field are especially encouraged to apply.
The person who fills this position will work in a research laboratory, shared tissue culture facilities of SBC (BSL2), shared instrument facilities (e.g. fluorescent and confocal microscopes) and in laboratories in the School of Biological & Chemical Science; and, also, at the UMKC, School of Medicine, as needed. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
The candidate must possess a Ph.D. in a relevant field. ABDs will be considered, but PhD degree must be in hand before start date.
Entry level or with one year’s post-doctoral experience
Full Time/Part Time
Full-Time, benefits eligible, 12-month, unranked, non-tenure track academic appointment.
$47,476 – 55,000. Salary is competitive and will be commensurate with experience and qualifications. The salary is based on NIH guidelines.
Position is open until filled. We will begin reviewing applications as they are received.
To be considered, you must complete the application which contains two (2) sections: 1. Name and Contact Information 2. Combine all application materials (a letter of interest, curriculum vitae, a list of at least five references) into one PDF or Microsoft Word document and upload as a resume attachment.
Limit document name to 50 characters. Maximum size limit is 11MB. Do not include special characters (e.g., /,&, %, etc.).
If you need technical assistance, please call (800) 488-5288.
Equal Employment Opportunity
Equal Opportunity is and shall be provided for all employees and applicants for employment on the basis of their demonstrated ability and competence without unlawful discrimination on the basis of their race, color, national origin, ancestry, religion, sex, pregnancy, sexual orientation, gender identity, gender expression, age, disability, protected veteran status, or any other status protected by applicable state or federal law. This policy shall not be interpreted in such a manner as to violate the legal rights of religious organizations or the recruiting rights of military organizations associated with the Armed Forces or the Department of Homeland Security of the United States of America. For more information, call the Vice Chancellor - Human Resources at 816-235-1621.
Reasonable accommodations may be made to enable individuals with disabilities to perform the duties and functions of this job. If you believe you may have difficulty performing any of the duties or functions of this job, please contact the Office of Affirmative Action at (816) 235-1323.
EEO IS THE LAW
To read more about Equal Employment Opportunity (EEO) please use the following links:
UMKC Statement on Diversity
UMKC values diversity as central to its mission as an urban-serving research university and as a driver of excellence in teaching and learning. UMKC embraces a broad spectrum of diversities, including race, ethnicity, culture, nationality, gender, age, sexual orientation, disability, linguistic ability, learning style, religion, socioeconomic and veteran status, life experiences, educational level and family structure. For more information on our diversity mission, visit the Office of Diversity and Inclusion website: http://info.umkc.edu/diversity/
UMKC is the largest comprehensive, fully accredited university in the Kansas City area. Our students come from all 50 states and over 85 countries, enriching our community with diverse perspectives. With more than 125 academic areas, our students have a lot of opportunities to explore on their way to discovering and creating their perfect career. We are at the heart of a thriving urban area where the city’s life and energy influence everything that happens here. We are Kansas City’s university and we can’t wait for you to join us! Find out more about UMKC in the About UMKC section of our website.
Details about UMKC’s community and the benefits of being an employee can be found on our careers page.