Post Doc

Employment Type: Staff - Regular

Employee Class: Post Doctoral Assoc FT-HSC

Bargaining Unit: BU Exempt

Shift: 1

Work Hours: 8:30 - 5:00

Hours Per Week: 40

FTE: 1

Location: HSC College

Department: Med Microbio & Immunology

Number of Openings: 0

Salary Range: $ 45,000.00 - 55,000.00

Grade: Post Doctoral Associate - PD01

Float: N/A

Rotate: N/A

On Call: N/A

Travel: N/A

Weekend/Holiday: N/A

Requisition ID: req3158

Position Control Number (PCN): T88250

Posting Period: Open Until Filled

Position Description:

The University of Toledo College of Medicine and Life Sciences is looking for two Postdoctoral fellows in the Department of Medical Microbiology and Immunology to work on National Institutes of Health (NIH) and EPA - funded projects study innate immune responses, particularly the interferon system, to protect against viral and non-viral diseases. The laboratory is interested in studying how the interferon system protects against virus infection. In this context, we are focusing on the key transcription factor Interferon Regulatory Factor 3 (IRF3), whose activities are required to inhibit viral replication in vitro and in vivo. We have shown that in addition to performing transcriptional functions, IRF3 also triggers direct apoptosis in virus-infected cells and the apoptotic pathway is critical for its antiviral activity (Glanz et al, Viruses 2020, Chattopadhyay et al Immunity 2016, J. Virol 2013, 2011, EMBO J 2010). We are interested to study, using knockout and knock-in mouse models, how this pathway regulates viral or non-viral diseases. IRF3, upon activation by virus infection, transcriptionally induces many antiviral genes, such as interferons and interferon stimulated genes (ISGs) (Chattopadhyay et al EMBO Rep 2015, mBio 2013). The protein products of these ISGs inhibit specific stages of viral life cycle, thereby inhibiting virus replication. Because all viruses cannot be inhibited by a single ISG, it is important to investigate virus-specific ISGs. Using high throughput screening approaches, we began to identify novel viral restriction mechanisms (Subramanian et al, JBC 2020, PLOS Pathogens, 2018). These mechanisms will be tested in vivo using appropriate viral pathogenesis models. Currently, we have several ongoing projects in our laboratory to study both pathways of IRF3 in viral and non-viral pathogenesis. Interested candidates should apply to this link below. Salaries and compensation will be based on first-authored publications and experience in the research area of our laboratory.

Qualifications:

Ideal applicants are expected to be highly organized, detail-oriented, and able to perform multiple research activities (multi-task) on a daily basis.  Occasional weekend and/or night laboratory work may be necessary.

Working experience with maintaining mouse colony, breeding transgenic mice, genotyping and functional characterization using such techniques as PCR, cloning, recombinant protein expression and purification, SDS-PAGE, western blotting, flow cytometry, fluorescence microscopy, and experience growing bacteria.

Ph.D. degree in biological/medical sciences (e.g., microbiology, molecular biology, biology, biochemistry, immunology) required.

Minimum five years laboratory research experience with either animal models or molecular biology techniques is required.  Experience with both is strongly preferred. 

Basic electronic word processing, database management, and data analysis skills are required.

 Applicant must be able to clearly speak and write technical data in English and have the ability to work independently.

Working Conditions:Applicant may work with hazardous or infectious materials or waste, chemicals, and be in proximity to unpleasant odors. Physical Requirements: 1. Visual acuity of 20/20 or corrected to 20/20 including color vision, where applicable: constant 67-100% 2. Ability to hear, with or without aides: constant 67-100% 3. Ability to orally communicate: constant 67-100% 4. Good manual dexterity: constant 67-100% 5. Ability to push, pull, roll, transfer/lift 50 pounds occasionally: Occasional 0-33%6. Ability to stand/walk/sit frequently: constant 67-100% 7. Ability to bend, reach, stoop, kneel frequently: constant 67-100% (Definitions: Never 0% Occasional 0-33% Frequent 34-66% Constant 67-100%)

The above list of duties is intended to describe the general nature and level of work performed by people assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the people so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct and control the work of employees under his/her supervision.

The University of Toledo is an equal opportunity, affirmative action employer. The University of Toledo does not discriminate in employment, educational programs, or activities on the basis of race, color, religion, sex, age, ancestry, national origin, sexual orientation, gender identity and expression, military or veteran status, disability, familial status, or political affiliation.

The University of Toledo provides reasonable accommodation to individuals with disabilities. If you require accommodation to complete this application, or for testing or interviewing, please contact the Human Resources Department at 419-530-4747 between the hours of 8:30AM and 5:00PM or apply online for an accommodation request.

Computer access is available at most public libraries and at the Office of Human Resources located in the Center for Administrative Support on the Main Campus of the University of Toledo, or at the satellite HR Office located at the Facilities Services Building, Suite 1000 on the Health Science Campus.