Post Doctoral Associate

Job description


Postdoctoral Fellow – Systemic Autoimmunity

Department of Medicine

University of Massachusetts Medical School


Design and carry out experiments to explore one or more of the following topics:  molecular mechanisms by which TLR9 negatively regulates T cell activation in murine models of systemic autoimmunity; regulation and gene expression profiles of skin-associated immune cells from cutaneous lupus patients and murine model of cutaneous lupus (Mande P, et al., 2018, JCI) by both high resolution flow cytometry and single cell RNAseq; immune defects of mice that express a gain-of-function (SAVI) mutation.  These projects include collaborations with Drs. John Harris and Kate Fitzgerald.

Expectations also include preparation of oral presentations for program/department research in progress meetings, submission of abstracts for poster and oral presentations at national/international meetings, and oversight of technician and/or student working on related projects.


Highly motivated investigator with a PhD in Immunology, Cell Biology, Molecular Biology or related discipline.

Working knowledge of cellular immunology, B and T cell development, and innate immune pathways.

Hands-on laboratory experience in relevant methodologies, trouble-shooting technical problems, and data analysis skills.

Experience in the following techniques preferred:  handling/injecting/genotyping mice, preparation of lymphoid and dermal/epidermal tissues for histology, isolation and cell culture of lymphocyte populations, multicolor flow cytometry, DNA/RNA purification and quantification, qPCR, enzyme-based immunoassays, and immunofluorescent/confocal microscopy, database comparisons.

Outstanding organizational and time management skills, as well as the ability to work both independently and as part of a team in a fast-paced environment.


Find out more about the UMMS research community at


To apply for this position:


Send your CV and the contact information for three references to [email protected]





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Job No:
Posted: 4/29/2021
Application Due: 4/27/2022
Work Type: Full Time