Research Assistant 1
Job Title: Research Assistant 1
Location: Case Main Campus
Full/Part Time: Full-Time
Job ID: 8777
Job Description POSITION OBJECTIVE
Working under moderate supervision, the Research Assistant 1 will perform research work in medical and related technical research projects in a basic science laboratory. The lab’s NIH-funded research is focused on understanding the postnatal development of the respiratory system, utilizing rodent models to investigate lung development in the setting of bronchopulmonary dysplasia and the effects that early exposure to oxidative stress, inflammation or mechanical stretch might have on long-term adverse consequences to the lung and heart. The research assistant will perform standard molecular techniques (PCR, electrophoresis, RNA extraction), animal work, tissue processing (immunohistochemistry), in vivo
and in vitro
physiology studies, tissue culture work and general lab maintenance. The research assistant will also collect, verify, record and compile data and information related to the ongoing research carried out in the lab. The goals of this translational research are to understand and develop therapies for the cardiopulmonary complications after preterm birth. This position will work with animals. ESSENTIAL FUNCTIONS
Perform research work involving use of laboratory skills. Conduct exposures and collect tissues, serum and lavage fluid from animals of various ages. Perform experimental methods include using immunohistochemistry and confocal/fluorescent imaging or performing western blots, PCR, ELISA and/or other associated molecular techniques on collected samples. Assess in vivo and in vitro airway and vessel physiology. (50%)Perform duties related to animal husbandry (mice/rats), including feeding and general maintenance of animal enclosures and ensuring health and well-being of the animals. (15%)Maintain records of experiments. This includes maintaining accurate and complete lab notes/records, present reports of lab duties including data collection, data analysis and experimental progress at weekly lab meetings. (10%) Maintain test equipment as necessary. Order laboratory supplies and reagents. (15%)
Participate in annual lab inspections and safety plan reviews, maintain general lab cleanliness and Environmental Health and Safety compliant chemical inventory. (5%)Present findings to visiting professors, collaborators and at regional/national meetings. (4%)Assist in training new students as needed. Perform other duties as assigned. (1%)
CONTACTSDepartment: Daily contact with other lab members holding similar positions as well as residents and fellows within the Division of Neonatology (UH Rainbow Babies and Children) who will also be conducting their own and in some cases overlapping research projects. Regular interactions with other lab members through which existing collaborations have been formed. Attend weekly department seminars (virtual at time of this posting) to promote interactions with neighboring labs and respective research interests. Monthly meetings within the Division of Neonatology at UH (virtual or in-person) will also be ongoing to enable interaction with physicians for group discussions relevant to the clinical significance of the lab’s overall research objectives. Weekly mandatory lab meetings with principal investigator to present research progress, results and data collection and to discuss goals and whether such goals have or have not been met.University: Occasional contact with other departments to share information.External: Limited contact with vendors and delivery personnel to exchange information.Students: Contact with students and trainees to exchange information. SUPERVISORY RESPONSIBILITY This position has no direct supervision of staff employees. QUALIFICATIONSEducation/Experience: Bachelor’s degree and 0 to 1 year of experience or Associate's degree in an approved biotechnology program and 0 to 2 years of experience required. REQUIRED SKILLS
Knowledge of commonly used concepts, practices and procedures within the biological sciences. An understanding of developmental respiratory physiology would be advantageous. Relies on instructions and pre-established guidelines to perform the functions of the job. Ability to operate laboratory equipment including microscopes and vibratomes for tissue sectioning. Ability to meet consistent attendance.Ability to interact with colleagues, supervisors and collaborators face to face.Previous experience working with animals and basics of rodent lung physiology and/or developmental biology is preferred. Knowledge and understanding of commonly-used concepts, practices and procedures associated with molecular techniques is also preferred (PCR, western blots, immunohistochemistry)Strong organizational skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills and proven ability to successfully follow-through on assigned projects.Research skills related to small animal handling (mice/rats) will be reviewed and evaluated by the Animal Resource Center. Must demonstrate compliance with Case Western Reserve University animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.Must demonstrate compassion for animals within Case Western Reserve University facilities and dedication to the Animal Resource Center’s mission. Must handle animals with care and respect at all times.Must be able and willing to learn new techniques, procedures, processes and computer gear to protect the health of the animalsProfessional and effective verbal and written communication skills and good interpersonal skills with the ability to work and communicate with various individuals within and external to the University.Ability to work effectively both independently and collaboratively within a team. Must be highly motivated, responsible, dependable and a self-starter. Ability to work with sensitive information and maintain confidentiality. Effective problem-solving skills; must demonstrate analytical skills, sound judgment and good decision-making. Must demonstrate flexibility and ability to work under pressure; must be able and willing to work in a fast-paced, changing environment and conform to shifting priorities, demands and timeline. Proficiency in Microsoft Office (ex: Word, Excel, PowerPoint), database applications and with internet navigation. Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health of animals, co-workers and self.
WORKING CONDITIONSGeneral laboratory environment: The lab is an open floor plan with abundant bench space for animal handling and manipulations. Ample desk space with computers are also provided. The lab is equipped with multiple fume hoods for preparation of animal tissues and use of hazardous and non-hazardous materials. Two rooms located adjacent to the lab are equipped with surgical areas for in vivo
and in vitro
measurements of lung and airway function and other surgical procedures, as well as microscopes and vibratomes for tissue imaging and processing. Neighboring labs are positioned adjacent to and in contact with the lab so the candidate should expect frequent interactions with respective lab members with similar research interests. Major physical demands include proper transportation and restraint of gas cylinders, transferring animals between the lab and the animal holding facility, as well as weekly changes of mouse/rat cages as needed. May have exposure to hazards. Employee will need to wear appropriate protective equipment such as gloves, coat and eyewear. Working conditions will require working at the bench in a molecular biology laboratory, working with mice/rats and other animal models in the laboratory and in the animal facility and when needed working outside standard working days or hours as required by the needs of a given experiment or time-dependent exposure (when reporting to work on holidays and/or weekends are necessary, arrangements for equitable weekly work hours will be discussed in advance with supervisor). Case Western Reserve University's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals." This position and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.Diversity Statement
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
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