Research Assistant 2
- Employer
- Case Western Reserve University
- Location
- Case Main Campus
View more
- Administrative Jobs
- Academic Affairs, Research Staff & Technicians
- Employment Type
- Full Time
- Institution Type
- Four-Year Institution
Job Details
Location: Case Main Campus
Regular/Temporary: Regular
Full/Part Time: Full-Time
Job ID: 8789
Job Description POSITION OBJECTIVEWorking under general supervision, the Research Assistant 2 will plan and carry out research projects in accordance with general research guidelines. The research assistant will work closely with other lab members and be responsible for analyzing data and presenting research results in scientific meetings. This position will focus on research involving molecular mechanisms of cardiac muscle contraction in models of heart failure, will be expected to assist in performing experiments of in vivo function in transgenic mouse models and will perform a wide array of cellular and molecular experiments using native cardiac tissues and recombinant proteins. Duties include planning and performing experiments on projects related to cardiac contractile function. This position will work with animals. ESSENTIAL FUNCTIONS
- Plan and carry out research projects that characterize the roles of myofilament contractile proteins in the regulation of cardiac muscle contraction. (25%) Manage animal resources used in experiments by keeping detailed records of animal inventory, setting up and checking breeding pairs for litters and separating cages at time of weaning. (10%)Conduct in vivo gene therapy experiments using intravenous and retro-orbital injection of AAV9 vectors in mice. (15%)Conduct a wide range of biochemical and functional studies of cardiac mechanics including: gel electrophoresis, gel purification, western blotting, kinase experiments, immunohistochemistry, expression and purification of recombinant proteins, and small animal echocardiography. (20%)Collect, organize and analyze research data for presentation in laboratory meetings. (15%)May assist in developing more efficient gene therapy and biochemical techniques. (5%)
- Oversee inventory and standard operating procedures. Maintain equipment, prepare buffer/media/reagents, and dispose biohazardous waste. Maintain lab records. Train new staff; direct the work of students. (5%)Perform other duties as assigned. (5%)
- Knowledge of commonly used concepts, practices and procedures in chemistry, physics, biochemistry and molecular/cellular biology and in vivo cardiovascular function. Prior experience with cell culture, protein expression/purification, confocal microscopy, small animal surgery, muscle mechanics experiments. Previous experience working with animals preferred. Must demonstrate compliance with Case Western Reserve University animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines. Must demonstrate compassion for animals within Case Western Reserve University facilities and dedication to the Animal Resource Center’s mission. Must handle animals with care and respect at all times.Must be able and willing to learn new techniques, procedures, processes, and computer gear to protect the health of the animals.Ability to follow instructions and pre-established guidelines to perform the functions of the job with minimal supervision.Strong organization skills and maintenance of laboratory records, with attention to scientific detail.Ability to multi-task, prioritize and give attention to detail in order to complete tasks and meet deadlines.Ability to effectively operate basic molecular and cellular biology laboratory equipment. Ability to problem solve effectively and assist in the development and implementation of alternative solutions as needed. Must demonstrate good judgment and logical decision making.Ability to work effectively, both independently and collaboratively within a team.Technical competence with software programs such as Microsoft Office (Word, Excel, and PowerPoint) and scientific graphics packages (such as Origin) is strongly preferred. Ability to learn and apply software programs and applications as needed.Ability to perform various molecular biology techniques and muscle mechanics experiments.Ability to learn and apply new techniques, ideas, processes, policies, functions, etc. Must be highly motivated and a self-starter.Ability to conform to shifting priorities, demands and timelines. Must be flexible in order to respond to project adjustments and alterations promptly and efficiently. Must be able to adapt to varying workloads and respond appropriately to stressful situations.Excellent verbal and written communication skills; good interpersonal skills with the ability to interact with colleagues, supervisors and customers face to face.Ability to follow through on assigned projects and provide timely follow-up as needed.Ability to meet consistent attendance.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
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Reasonable AccommodationsCase Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
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Organization
Working at Case Western Reserve University
Case Western Reserve University is among the nation's leading research institutions. Founded in 1826 and shaped by the unique merger of the Case Institute of Technology and Western Reserve University, Case Western Reserve is distinguished by its strengths in education, research, service and experiential learning. Located in Cleveland's University Circle, we offer nationally recognized programs in the arts and sciences, dental medicine, engineering, law, management, medicine, nursing and social sciences.
Student enrollment exceeds 9,800 students, forty percent of whom are undergraduates. Facultyand students hail from more than 90 countries, with academic interests that reach every region of the world. Case Western Reserve, with the support of individuals, corporations and foundations, aids nearly 100 designated research centers.
As a service-oriented institution dedicated to civic leadership, Case Western Reserve seeks individually and collectively to prepare our students to improve the human condition and to direct the benefits of discovery toward a better society. This effort is not limited to the university's classrooms, laboratories, libraries, residence halls and athletic fields, but includes partnerships with many other institutions. We build these partnerships believing that our ability to improve the human condition should begin in our own community.
Case Western Reserve University remains Ohio's top-ranked school among the nation's premier national universities, as ranked by U.S. News & World Report and is the only Ohio institution ranked in the top 50 nationally. We promote a culture of inquiry marked by rigor, creativity, curiosity, innovation, respect, sensitivity and open communication of ideas.
The university supports interdisciplinary partnerships in education and research with numerous faculty holding joint appointments in more than one Case Western Reserve school or department, as well as at neighboring institutions. These relationships launched many of the unique pairings of science, business and liberal arts into the centers and programs that enhance the undergraduate and graduate experience at the university. Our dual degree programs enrich the educational experience for those students who choose to balance the technical requirements of engineering or the sciences with a strong interest in the humanities.
With more than $375 million in research funding annually, the university attracts outstanding undergraduate and graduate students along with renowned faculty whose research has made significant contributions to the way we live and work. Case Western Reserve counts 15 Nobel laureates among our alumni and current and former faculty, including the first American scientist to ever receive the prize.
Our students' experiences in cultural institutions, clinics, social service agencies and industry are not viewed as “extra-curricular,” but create the learning experience that defines a Case Western Reserve education. The university's service programs in the Cleveland Municipal School District have impacted more than 145,000 students with more than 43 signature programs. The university has launched more than 580 community partnerships on the local, national and international levels. Annually the university sponsors Case for Community Day, an event where hundreds of Case Western Reserve employees and students lend their time and talent to targeted community development projects in the Greater Cleveland area.
Our alumni number more than 110,000 and constitute a “who's who” of every profession. Alumni represent one of the university's strongest resources, playing a vital role in campus life through their work as advisors, mentors, friends and advocates.
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