RESEARCH SCIENTIST

Job description

School of Medicine:

Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.

Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

Overview
The Moody Discovery Laboratory focuses on understanding the B cell responses during the earliest stages of HIV, influenza, and syphilis infection, providing pre-clinical and translational support for downstream human clinical studies that fall within DHVI's mission of performing research against infectious diseases that impact global health. The lab is a resource for both nonhuman and human cellular phenotyping, flow characterization, staining and analysis at DHVI. Further, the Moody Discovery Laboratory performs a variety of assays to support the DHVI mission; including cellular and serological assays, molecular biological techniques, protein production, and viral isolate propagation.

Responsibilities

  • Independently lead and execute major and complex scientific projects within the Moody Discovery laboratory, serve as the point person for assigned projects and coordinate collaborative science among investigators within DHVI and externally to effectively meet the scientific milestones and project deadlines
    • Must understand goals, aims, and timelines for multiple projects
    • Must communicate thoroughly, effectively, and timely with various levels across DHVI and external collaborators
    • Must provide written data to multiple levels, as well as prepare and present logical data updates
    • Must estimate experimental costs in advance of work to ensure funding is available and that work planned is within scope of sponsored programs
  • Design and execute experiments and interpret data in support of the influenza programs, to include:
    • Viral production activities, including isolation and propagation
    • Bioinformatic analysis of viral envelope and antibody sequences
    • Large-scale recombinant protein production and purification by transient transfection including antibodies, viral envelope, and host proteins
    • Large-scale cell culture
    • Adapt expression methods to mitigate challenges encountered with routine expression systems
    • Characterize the binding and neutralization phenotypes of monoclonal antibodies and investigate the ontogeny of vaccine-induced neutralizing antibodies
    • Investigate structure-function relationships of antibody recognition of influenza
    • Based on experimental findings, proactively design follow up experiments.
  • Work collaboratively with Moody Lab Leadership to advance activities on other projects, which may include:
    • Design and manage preclinical animal experiments
    • Work with Moody Lab leadership to write and maintain IACUC protocols, training, etc.
    • Train laboratory staff and DHVI trainees
    • Develop and optimize new assays for the laboratory
    • Ensure materials and reagents are available for ongoing projects
    • Perform preventative maintenance on laboratory equipment as required
  • Under the direction of Dr. Moody, prepare publication-quality data for manuscripts and reports using various graphical software applications (Ai, Prism, etc.), as well as draft manuscript language
  • Perform other related duties as necessary and requested

Education, Skills, & Experience Requirements

  • Min Degree Requirements: Ph.D. or equivalent doctorate (e.g. Sc.D., M.D., D.V.M.).
  • Other Credential/Experiential Requirements:
    • 5 + years of postdoctoral experience conducting scientific research
    • Multiple publications and notable significant contributions to scientific research
    • Must be detail-oriented, well organized and approach procedures with critical thinking of the technical aspects
    • Excellent oral and written communication skills
    • Must be team oriented and able to work effectively in a highly collaborative work environment
    • Must be able to manage multiple and rapidly changing priorities and have the ability to learn and apply new skills and concepts

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

 

 

 

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Job No:
Posted: 4/7/2021
Application Due: 7/10/2021
Work Type: Full Time
Salary: