Research Senior Instructor
University of Colorado – School of Medicine
Senior Research Instructor
The University of Colorado Denver l Anschutz Medical Campus seeks individuals with demonstrated commitment to creating an inclusive learning and working environment. We value the ability to engage effectively with students, faculty and staff of diverse backgrounds.Nature of Work:Senior Research Instructor in the laboratory of Huntington Potter, Ph.D., who will train and supervise lab personnel, and will design and perform basic and translational research such as animal behavioral science, neurobiology, molecular biology, biochemistry, and cellular biology to address key questions about the molecular mechanisms underlying Alzheimer’s disease (AD), Alzheimer’s disease related dementias (ADRD), Down syndrome (DS), autism, and other related neurological disorders. Job Responsibilities:This is a full-time position located on the AMC campus in Aurora, CO. The Senior Research Instructor will be expected to perform high quality scientific research by working independently. The Senior Research Instructor will have supervisory and mentorship responsibilities of fellows, graduate students, and professional research assistants, and will also present the results of their research studies and experiments in both internal and external scientific meetings and symposia. The Senior Research Instructor will be designing and performing animal behavior tasks and neuropathological outcome assessments in rodent models of AD, DS, ADRD, aging, and autism and will be able to teach these methods and related tasks to other laboratory personnel.Laboratory duties will include the independent design of experimental plans, pre-clinical studies in animal models including performing animal behavior tasks and investigating brain pathology, supervision of fellows, graduate students, and professional research assistants, and writing grant applications and manuscripts.Salary and Benefits:The salary range for this position has been established at $70,000 to $77,000.The salary of the finalist(s) selected for this role will be set based on a variety of factors, including but not limited to, internal equity, experience, education, specialty and training.The above salary range represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services.University of Colorado Denver | Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background checks for all new employees prior to their employment.The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.Benefits: https://www.cu.edu/employee-services/benefits.Total Compensation Calculator: https://www.cu.edu/employee-services/total-compensationDiversity and Equity:Please click here for information on disability accommodations: http://www.ucdenver.edu/about/departments/HR/jobs/Pages/JobsatCUDenver.aspx Office of Equity: https://www1.ucdenver.edu/offices/equity The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.
- Doctoral degree in Neurology, Neurobiology, Molecular and/or Cell Biology, Biochemistry, or Pharmacology. Minimum of eight years of laboratory research experience related to AD and/or DS.
- Consistent track record of publications and meeting abstracts that reflect research accomplishments in AD and DS.Experience in preparing patent applications.Prior experience co-mentoring graduate students, rotating/summer students, and other lab members.Experience in training lab members on projects requiring expertise in animal behavior, harvesting and dissecting central and peripheral tissues/organs, and immunohistochemistry. Experience with animal behavior testing, neurobiology, molecular biology, biochemistry, and cellular biology techniques, including working with in vivo animal models of AD and DS.Immunohistochemistry/Immunofluorescence and microscopy imaging, proteomics, immunoblot analysis, ELISA assays, and mammalian cell culture.An ability to develop new ideas/plans in research on AD, DS, and related disorders, and to anticipate and pursue new directions as needed.Capability to troubleshoot projects and engage in critical thinking.Strong knowledge of the fields of neurobiology and neurodegenerative disease, especially AD and DS.Self-motivated and independent with effective time-management skills.Strong knowledge about rodent brain anatomy, dissection of brain and peripheral tissues, stereotaxic brain surgery, intraperitoneal (i.p.) and subcutaneous (s.c.) injection of drugs, microinjection, and microdialysis in mice/rat brain regions. Strong knowledge of immunohistochemistry/immunofluorescence image analysis using Image J and CellSens software.Ability to evaluate behavioral assessments for learning/memory deficits, data analysis, and interpretations.An outstanding ability to work with neuronal, glial, and inflammatory markers for understanding disease progression, pathology, and possible treatments.Strong knowledge using the high-throughput proteomics technique of Reverse Phase Protein Arrays to identify abnormalities in signaling pathways associated with different disease conditions.An ability and desire to learn new techniques as needed.Excellent project and data management skills.Excellent written and verbal communication skills.Capable of leading a research team and participating in collaborative projects.
- 10+ years of working experience in the fields of AD and DS.Experience co-mentoring graduate students and teaching/supervising lab personnel.A long-term commitment to research in the AD, DS, and related disorders is highly desirable.Experience working with different animal models of AD and DS.Hands-on experience performing behavioral assessments in rats/mice.Experience performing pre-clinical studies in animal models of neurodegenerative disease.Experience evaluating the potential efficacy of granulocyte-macrophage colony-stimulating factor for learning/memory and brain pathology in mouse models of AD and DS.Experience working with NMDA receptor antagonists in animal models of AD and DS.
Job Category: Faculty
Primary Location: Aurora
Posting Date: Apr 5, 2021
Unposting Date: Ongoing