Post-Doctoral Fellow

Job description


University of Colorado – School of Medicine

Post-Doctoral Fellow


The University of Colorado Denver l Anschutz Medical Campus seeks individuals with demonstrated commitment to creating an inclusive learning and working environment.  We value the ability to engage effectively with students, faculty and staff of diverse backgrounds.

Nature of Work, Research Project

Our group takes an integrative approach that combines biophysical, biochemical, and biological methods to probe macromolecular structure, dynamics, and function for enzymes involved in disease. The work includes two projects:

  1. Using NMR to elucidate the role of enzyme motions within a family of enzymes.  Both structural ensembles and relaxation methods are being used to understand how active site motions are globally controlled (allostery) and how these motions dictate catalytic function within a family of enzymes found in mammals, insects, and bacteria.
  2. Using Cryo-EM to determine the molecular mechanisms of giant bacterial enzymes that act as virulence factors.  A combination of cryo-EM, biochemistry, and collaborative biological studies are used to fully characterize a functionally conserved family of bacterial enzymes that promote infection.
  3. Using biological (tissue culture) and biochemical methods to characterize Toll/Interleukin Receptor (TIR) signaling and its hijacking by bacterial TIR-containing proteins.
Professional Field

Biophysics & Biochemistry

Supervision Received

This position is supervised by Elan Eisenmesser, PHD, Associate Professor, Department of Biochemistry and Molecular Genetics

Supervision Exercised


Job Description

The applicant should have experience in biophysical and biological methods in order to apply them to address fundamental questions in multiple biological systems (NMR, cryo-EM, tissue culture).  We seek a bright, energetic, motivated individual that is interested in understanding the role that macromolecular dynamics and structure play in enzyme function.


The salary range (or hiring range) for this position has been established at $53,760 to $60,780 and will follow current NIH postdoctoral fellow scale.

The salary of the finalist(s) selected for this role will be set based on a variety of factors, including but not limited to, internal equity, experience, education, specialty and training.

The above salary range represents the University’s good faith and reasonable estimate of the range of possible compensation at the time of posting. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services.

University of Colorado Denver | Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background checks for all new employees prior to their employment.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.


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Diversity and Equity:

Please click here for information on disability accommodations: 

Office of Equity:

The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

Minimum Qualifications

    Doctoral Degree in Chemistry, Biochemistry, or BiophysicsExperience in macromolecular NMR studiesApplicants with no NMR experience will not be considered.
Desired Qualifications

Considering the comprehensive list of techniques utilized in our lab, experience with other techniques beyond NMR would be beneficial (biochemistry assays and other biophysical techniques).

Knowledge, Skills, and Abilities

    Strong aptitude for independent problem-solving, Strong computer skillsExcellent communication, oral, and written skills are necessaryApplicant should be motivated to extend his/her training to include other techniques such as cryo-EM. 
Applicants must meet minimum qualifications at the time of hire. 

Job Category: Faculty
Primary Location: Aurora
Schedule: Full-time
Posting Date: Mar 30, 2021
Unposting Date: Ongoing




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Job No:
Posted: 4/1/2021
Application Due: 6/30/2021
Work Type: Full Time