Job description

School of Medicine:

Established in 1930, Duke University School of Medicine is the youngest of the nation’s top medical schools. Ranked tenth among its peers, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where traditional barriers are low, interdisciplinary collaboration is embraced, and great ideas accelerate translation of fundamental scientific discoveries to improve humanhealth locally and around the globe.

Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.

A Lab Research Analyst II position is available in the laboratory of Dr. Michael S. Krangel, PhD, in the Department of Immunology at Duke University School of Medicine. The Krangel laboratory is interested in the molecular regulation of antigen receptor recombination and repertoire formation in developing T lymphocytes, making use of mouse genetic models.

The ideal candidate will have a Bachelor’s degree or Master’s degree in life sciences with hands-on experience in standard molecular biology and immunology techniques. The lab analyst will perform experiments under the guidance of the principal investigator, will interact closely with students and postdoctoral fellows, and will be expected to work with laboratory mice. The candidate will also have responsibility for laboratory organizational tasks such as ordering, laboratory safety, and mouse colony management.

Representative publications:

Naik AK, Byrd AT, Lucander A, Krangel MS. 2019. Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes. J. Exp. Med. 216:231-243.

Chen S., Luperchio TR, Wong X, Doan EB, Byrd AT, Roy Choudhury K, Reddy KL, Krangel MS. 2018. A lamina-associated domain border governs nuclear lamina interactions, transcription and recombination of the Tcrb locus. Cell Reports 25:1729-1740.

Carico ZM, Roy Choudhury K, Zhang B, Zhuang Y, Krangel MS. 2017. Tcrd rearrangement redirects a processive Tcra recombination program to expand the Tcra repertoire. Cell Reports 19:2157-2173.

Chen L, Carico Z, Shih HY, Krangel MS. 2015. A discrete chromatin loop in the murine Tcra/Tcrd locus shapes the TCRd and TCRa repertoires. Nat. Immunol. 16:1085-1093.

Minimum Qualifications


Work requires a bachelor's degree in botany, biology, zoology, psychology or other directly related scientific field.


Work requires four years of research experience. A related master's OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE degree may offset required years of experience on a 1:1 basis, e.g., a two year master's degree in lieu of two years of experience.

Duke is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essentialjob functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.




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Job No:
Posted: 1/20/2021
Application Due: 4/28/2021
Work Type: Full Time