Senior Research Investigator
Job location: Smilow Center for Translational
Employment Type: Full-time
Posted data: 2021-01-12
University OverviewThe University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.Posted Job TitleSenior Research InvestigatorJob Profile TitleResearch Investigator, SeniorJob Description SummaryThe Senior Research Investigator will devote his/her time conducting research on the area of the role of the UPR/ISR in tumor progression and metastasis. She/he will perform experiments aimed at delineating the role of the transcription factor ATf4 in establishing the premetastatic niche and the role of ATF4 downstream effectors (collagen, ASNS etc) in this process. Employee will work with the PI, research specialists, as well as graduate and undergraduate students to coordinate and execute experiments in these areas including reviewing their experimental data and suggesting future experiments. A significant percentage of his/her time will be devoted to help the PI create grant proposals involving the areas listed above as well as prepare his/her own applications for intramural and extramural funding.Job Description
The Senior Research Investigator will devote his/her time conducting research in the areas of study of the tumor microenvironment and development and testing of new radiation response modifiers. This position requires the employee to be able to work with a great deal of independence in devising new areas of investigation and designing experiments.The investigator will work on delineating the role of the Unfolded Protein Response and Integrated Stress Response (UPR/ISR) in the tumor stroma (fibroblasts, immune cells, and endothelial cells) in promoting tumor growth.She/he will also engage in developing new models of proton radiation damage using different mouse strains and analyze the combined effects of radiation and UPR/ISR modifiers in the response of normal tissue to radiotherapy.Much of this work will be conducted in tumors grown in mice.Employee will work with the PI, research associates and students to coordinate and execute experiments in these areas including reviewing their experimental data and suggesting future experiments.A significant percentage of his/her time will be devoted to help the PI create grant proposals and also submit grant proposals on their own.
Highly advanced professional discipline. M.D., Ph.D., or equivalent doctoral degree and 5-7 years of experience is required.
Position contingent upon funding.
Office, library, computer room; Requires extensive safety training; Exposure to chemicals; Requires protective devices
Typically sitting at a desk or table; Typically standing or walking; Intermittently sitting/standing/stooping
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.Special Requirements
Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.