Permanent Staff (EHRA NF)Department:
Lineberger Compr Cancer Center-426801Working Title:
Research AssociateAppointment Type:
EHRA Non-FacultyPosition Posting Category:
Research ProfessionalsSalary Range:
Commensurate with ExperienceFull Time/Part Time?:
Full-Time PermanentHours per Week:
20036177Posting Open Date:
01/25/2021Open Until Filled:
NoProposed Start Date:
THIS IS A REPOST. PREVIOUS APPLICANTS ARE STILL BEING CONSIDERED AND NEED NOT REAPPLY.
The lab is interested in how signals from membrane receptors are transduced to the nucleus altering gene expression, cell shape, proliferation and differentiation. We are particularly interested in tyrosine-specific protein kinases in breast and prostate cancer, as well as lymphoma/leukemia. A second project investigates a novel transmembrane tyrosine kinase, Mer, cloned and sequenced in our lab. We are attempting to define the mechanism by which a tyrosine kinase sends anti-apoptotic signals without stimulating proliferation and how it results in chemoresistance in leukemia and other cancer cells. Experimental goals include characterizing circulating and tumor-infiltrating lymphocyte populations in correlative studies and murine models of cancer immunology, analysis of the genetic diversity of T cell receptor and B cell receptor repertoires, and gene-expression profiling of the tumor microenvironment using next-generation sequencing. The responsibilities of this position include isolation and characterization of tumors and the tumor immune microenvironments. Examples include, serving as the technical and functional expert in a variety of research related techniques, collaborating and consulting effectively with a large, dynamic team of clinical and research colleagues as well as the use of bioinformatics techniques to analyze sequencing data and prepare data reports.Educational Requirements:
Bachelor’s degree in a discipline related to the research and 3 years of experience, Masters, PhD preferred.Qualifications and Experience:
Certification in Flow Cytometry and Molecular Diagnostics or Genetics is recommended, as is facility with basic scripting in the Python and R programming languages, though these are not required.Particular expertise with human patient clinical samples preferred.Equal Opportunity Employer :
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or status as a protected veteran.