Postdoctoral Research Associate

Job description

Position Title:

Postdoctoral Research Associate

Vacancy ID:

PDS002923

Department:

Marsico Lung Institute - 426401

Position Type:

Postdoctoral Scholar

Salary Range:

Dependent on Experience

Full-time/Part-time:

Full Time

FTE:

1.0

Proposed Start Date:

01/04/2021

Estimated Duration of Appointment:

12 Months

Posting Open Date:

11/19/2020

Posting Close Date:

11/23/2020

Open Until Filled:

No

Work Location:

Chapel Hill, NC

Position Summary:

The Postdoctoral Research Associate will focus on understanding the critical roles of transcription factors in mediating mucus production/secretion and inflammatory responses during Th2 (by IL-13, IL-4 cytokines in asthma) and non-Th2 dominated inflammation (by IL-1? and IL-1? cytokines in CF). Further, this position is expected to study the regulation of the MUC5B gene expression, which can be influenced by its promoter polymorphism rs35705950 locus that is associated with pathogenesis of IPF. The postdoc is expected to use both transgenic/knockout mouse models, primary normal and diseased human bronchial epithelial cells coupled with CRISPR-Cas9 technology to address the key roles of transcription factors in respiratory epithelial cells that regulate secretions of mucus and ion/water, and innate host defense that are highly relevant to pathogenesis of chronic muco-obstructive lung diseases.

Educational Requirements:

PhD and/or MD.

Qualifications and Experience:

Prefer candidate to have the experience of performing pulmonary biology research and work with mouse genetic models, human primary airway cells culture, gene editing, scRNA-seq and confocal imaging techniques that are required for gene/protein expression and functional analysis.

Equal Opportunity Employer:

The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or status as a protected veteran.

Special Instructions:

N/A

 

 

 

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Job No:
Posted: 11/20/2020
Application Due: 11/23/2020
Work Type:
Salary: