Research Assistant 3
Job Title: Research Assistant 3
Location: Case Main Campus
Full/Part Time: Full-Time
Job ID: 8574
Job Description POSITION OBJECTIVE
- Manage the care, maintenance, breeding, weaning, genotyping and studying custom transgenic/ xenograft animal models of colon and esophageal cancer. (23%)Working closely with the principal investigator, develop genetically engineered mouse models of colon and esophageal cancer. Generate Xenograft and Patient derived Xenograft (PDx) colon/esophageal tumor models in immune deficient mice, derived from cancer cell lines and/or freshly-obtained patient biopsies. (23%)Formulate custom drug/chemical compounds and treatment of animals via intraperitoneal, intravenous, oral gavage, subcutaneous, or through diet/water. Obtain time-course measurements as appropriate. (14%) Dissect and isolate organs/tissues for subsequent cold storage and/or formalin fixation. Extract DNA/RNA/Protein from animal tissues for subsequent molecular studies. (7%)Devise new protocols and techniques for research projects involving a high degree of skill and training. Amend and/or update animal protocols and procedures as appropriate. (6%)Evaluate adequacy of techniques; study and test new procedures and analyzes data. (6%)Coordinate laboratory/research activities, including maintaining detailed descriptions of experimental methods/protocols, inventorying of all samples stored in repository and documenting the data on a routine basis. (6%)May monitor the laboratory budget. (6%)May co-author research projects, and assist with grant proposals and manuscripts related to animal research as appropriate. (6%)
- May supervise students and technicians. (2%)Perform other duties as assigned. (1%)
- Must have basic knowledge in animal genetics and prior work experience with xenograft and genetically-engineered mouse models. Prior work experience with mouse models of gastrointestinal cancers will be preferable. Proficiency in animal care, handling, breeding, maintenance, and genotyping. Prior experience in dissection and isolation of organs/tissues from mice. Proficiency in extraction of DNA/RNA/Protein from animal tissues and experience with routine techniques such as PCR and Western Blot. Must have basic computer skills (including use of MS Word, Excel) for data entry and record keeping. Must have strong organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Must demonstrate flexibility and willing to work in a fast-paced, changing environment, and conform to shifting priorities, demands and timeline. Willingness and ability to rely on and follow instructions and pre-established guidelines to perform the functions of the job.Demonstrate the ability to effectively and professionally communicate and work with various individuals from a broad spectrum of disciplines, technical and educational backgrounds within the department, School and University, and with individuals outside the University.Must demonstrate compliance with university animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines. Must demonstrate compassion for animals within university facilities and dedication to the Animal Resource Center’s mission. Must handle animals with care and respect at all times. Must be able and willing to learn new techniques, procedures, processes, and computer gear to protect the health of the animals. Ability to meet consistent attendance.Ability to interact with colleagues, supervisors and customers face to face.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.