Senior Scientist in Viral Diagnostics
Senior Scientist position in viral diagnostics is available in the Myhrvold and Notterman laboratories. The Myhrvold Lab at Princeton University develops cutting-edge, CRISPR-based technologies to study RNA viral infection and RNA transcription, regulation, and localization. We are also developing CRISPR-based viral diagnostics and antiviral therapies with the aim of creating a rapid development platform for new viral diagnostics and therapies, in close collaboration with Pardis Sabeti's lab at the Broad Institute of MIT and Harvard. We have applied several CRISPR-based technologies to aid in the global response to the COVID-19 pandemic. Princeton is testing student, faculty, and staff saliva samples at a clinical laboratory on campus. The laboratory employs approved qPCR technology and will make excess samples available for assay development and comparative analysis. The position offers an opportunity to use the CARMEN technology, a massively multiplexed approach for nucleic acid detection, for viral surveillance on the Princeton campus, working in close collaboration with a clinical laboratory. This is a unique opportunity to help develop and use a novel technology with the potential for immediate public health benefits. Experience with two or more of the following is a plus: CRISPR-Cas13; bioengineering; molecular biology, RNA biochemistry, nucleic acid detection, microscopy; or next-generation sequencing. A PhD is required. This position is for one year with the possibility of renewal contingent on satisfactory performance and funding. Responsibilities *Plans, develops and implements new processes and protocols to support the research study and maximize/extend study capabilities including, but not limited to, study manuals. *Conducts experiments to test CRISPR-based diagnostics using samples from the clinical lab at Princeton. *Reviews and reports study progress and recommends revisions, amendments, and other study changes. *Reviews scientific literature; evaluates and recommends applicable techniques and procedures. *Provides scientific and technical support in determining the plan, design and execution of research project ensuring specified study objectives are met. *Creates data for use in grant submissions and helps develop new proposals for research including obtaining financial support. *Prepares results and may co-author scientific papers for presentation and publication. *Coordinates with the PI to manage purchasing and expenditures for the project. Qualifications Essential: *Ph.D in the biological sciences with minimum 3-5 years relevant research experience required. *Excellent interpersonal and communication skills (written and verbal), with ability to interact effectively with all levels of constituency. *Demonstrated experience in budget management and oversight of financial operations. *Have a basic understanding of the science performed by researchers in order to facilitate collaborations. *Proven ability to take initiative, to formulate and implement action plans, and to meet firm deadlines. *Proven ability to accomplish tasks with high administrative complexity. *Comfortable working without explicit instructions and ambiguity in the role, as this is a new position and a new study. *Accuracy and organization in record keeping. *Proficiency with Microsoft Office Suite. *Must complete IRB CITI training Preferred: *Experience with clinical diagnostics, RNA biochemistry, or next-generation sequencing. *Experience working in higher education research and teaching environment. To apply, please submit a cover letter, CV, and contact information for three references at https://www.princeton.edu/acad-positions/position/18461.