Research Assistant 2

Job description

Job Title: Research Assistant 2
Location: Case Main Campus
Regular/Temporary: Regular
Full/Part Time: Full-Time
Job ID: 8563

Working under general supervision, plan and carry out cancer research in accordance with general plans. The research is on the role of Eph receptor tyrosine kinase signaling in tumor development of progression. The laboratory studies the molecular mechanisms that regulate tumor cell migration, adhesion and proliferation in vitro, and applies the basic knowledge to understanding tumor initiation and metastasis in vivo. Current focus of research is on Eph/ephrin signaling in the malignant progression of brain tumor and prostate cancer. A diverse array of modern technologies including genetically engineered mouse model (GEMM), single molecule imaging in live cells, bulk RNA-seq/single cell RNA-seq, and tumor immune surveillance/therapy are used in the lab to delineate the molecular pathways initiated by Eph/ephrin systems, and to develop new therapeutic agents for the prevention and/or treatment of human cancer. This position will work with animals.


    Plan and carry out project in accordance with general plans. employing molecular, cellular and biochemical approaches. (15%)Conduct a series of experiments to supply scientific information as part of a larger project. Perform tissue processing and analysis including routine histology, immunohistochemistry, frozen sections, tissues lysis and immunoblot. (20%)Perform animal husbandry, breeding, genotyping, colony maintenance, and animal experiments. (25%)May assist in developing improved techniques, projection methods or procedures IN of molecular biology, cell biology and protein biochemistry. (10%)Collect and analyze how the regulation of progenitor properties of normal and tumor stem cells by Eph-ephrin bidirectional signaling. (10%)Maintain certain equipment and/or laboratory facilities. (7%)Oversee inventory and order supplies for the lab. (10%)


    Train new staff; direct the work of students. (2%)Perform other duties as assigned. (1%)


Department: Daily contact with supervisor to discuss research and maintain workflow.

University: Occasional contact with purchasing to share information.

External: Limited or no contact with vendors to exchange information.

Students: Regular contact with post-doctoral fellows and student employees regarding research in the lab.


This position has no direct supervision of staff employees. Train new staff; direct the work of students.


Education and experience: Bachelor's degree and 1 to 3 years of related experience or Associate's degree in an approved biotechnology program and 2 to 4 years of experience. Valid drivers license.


    Knowledge and understanding of commonly-used concepts, practices, and procedures within the field of molecular biology, cell biology and protein chemistry.Ability to perform small animal surgery and tissue staining. Ability to demonstrate compliance with CWRU animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AALAC guidelines and other applicable regulatory guidelines. Demonstrated ability to show compassion for animals within CWRU facilities and dedication to the Animal Resource Center’s mission. Ability to handle animals with care and respect at all times. Previous experience working with animals (colony maintenance, genetically engineered mice tumor xenograft, and carcinogenesis preferred).Ability to meet consistent attendance.Ability to interact with colleagues, supervisors and customers face to face.Proficiency in computer skills.

Working Conditions

Major hazards include frequent handling of human cell lines and mouse tissues. Infrequent exposure to potentially toxic materials such as paraformaldehyde and ethidium bromide. Personal protective equipment is required when working with chemicals or animals. Occasional driving to use Core facilities at neighboring institutions. Possible travel out of town to attend conferences to present scientific results.

Case Western Reserve University’s animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the ‘Guide for the Care and Use of Laboratory Animals’ appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals”; This position, and all animal research personnel, are subject to internal compliance to School of Medicine Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.

Diversity Statement

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.


Reasonable Accommodations

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.





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Job No:
Posted: 11/17/2020
Application Due: 2/15/2021
Work Type: