Permanent Staff (SHRA)Is this an internal only recruitment?:
Research Specialist - JourneyWorking Title:
Research SpecialistPosition Number:
P012121Budgeted Hiring Range:
$49,500 - $58,000Pay Band Information:
To learn more about the pay band for this branch and role, please see the Career Banding rates spreadsheet.Salary Grade Equivalent:
Full-Time PermanentHours per week:
M-F, 8:00am – 5:00pmDepartment Name and Number:
Lineberger Compr Cancer Center-426801Date First Posted:
Chapel Hill, NCPosition Posting Category:
Research ProfessionalsDepartment Description:
The UNC Lineberger Comprehensive Cancer Center, founded in 1975, is a National Cancer Institute (NCI)-designated comprehensive cancer center. The Center’s mission is to reduce cancer occurrence and death in North Carolina and the nation through research, treatment, training and outreach.
The Rubinsteyn laboratory investigates the determinants of adaptive immune responses and works on developing precise vaccines for both mutant and viral antigens. The lab pursues these goals through both computational methods as well as experimental work to parameterize and validate modeling. In the context of cancer, this corresponds to building better predictive models of T-cell immunogenicity, optimizing vaccination approaches to boost anti-tumor T-cell responses, and uncovering a broader set of mutant antigens against which personalized vaccination can be deployed.Equal Opportunity Employer:
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.Position Description:
This position is for a Research Specialist within the Tumor Immunogenomics Lab (TIL) initiative that will be a collaborative research program between Dr. Rubinsteyn, Dr. Benjamin Vincent, , and Dr. Jared Weiss. TIL will integrate the wet lab research portfolios of Drs. Vincent, Rubinsteyn, and Weiss in the areas of antigen identification and targeting via novel therapeutics, including work being done in therapeutic neoantigen vaccination and epitope-optimized SARS-CoV-2 vaccination.
The person filling this role will need to work on several projects related to T-cell immunity in the context of vaccination against viral antigen, vaccination against mutant cancer antigens and identification of potentially immunogenic mutations in cancer cell lines. Project management work will include designing, executing, and troubleshooting, informed by the scientific literature and with input and direction from the principal investigators. This will require a high degree of scientific independence. This person will also need to prepare formal scientific communications including reports, presentations, manuscripts, and figures/text for funding proposals.
The specific laboratory work associated with this position includes maintaining cell cultures under various mutagenic conditions and quantifying T-cell responses to both tumor and viral antigens. This work also includes analyses of the genetic diversity of T cell receptor (TCR) repertoires and gene-expression profiling using next-generation sequencing and single-cell sorting and sequencing techniques in the same models. Experiments will be done with both human and murine immune cell populations, after exposure to various forms of cancer or viral antigens. This position will require the person filling it to be a part of a multidisciplinary team with regular contact with scientists from other disciplines. Finally, the person filling this position should have a high degree of capacity to work independently as well as collaboratively as part of a multidisciplinary team, including well-developed skills in project management.Minimum Education and Experience Requirements:
Bachelor’s degree in a discipline related to the area of assignment; or equivalent combination of training and experience. All degrees must be received from appropriately accredited institutions.Essential Skills, Knowledge and Abilities:
The applicant must have significant experience in cell culture, flow cytometry, and T-cell assays such as ELISPOT or ICS.Preferred Qualifications:
Master’s degree or higher in Biology, Biochemistry, Biophysics, Bioinformatics/Computational Biology, Chemistry, Clinical Laboratory Science, Genetics, Immunology, Medical Technology, Microbiology, Molecular Biology, Physiology, Pharmacology, or Zoology; or Bachelor’s degree in one of the above fields and 1+ years of relevant work in industry.
Experience with project management and sample tracking with LIMS, mLIMS and/or similar systems is recommended.Position/Schedule Requirements: