Manager, QC Cloning & Characterization

Job description



Manager, QC Cloning & Characterization

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title
Manager, QC Cloning & Characterization

Job Profile Title
Manager D

Job Description Summary
The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Continuation of all GTP positions is contingent upon funding.

Job Description

The Gene Therapy Program (GTP) Vector Operations team supports the development, manufacturing and analytical characterization of drug products for the treatment of both genetic and infectious diseases. GTP's platform vector technology, manufacturing processes and analytical capabilities have supported the development of gene therapies for a number of investigational new drug (IND) applications as well as vaccine development for the prevention of pandemic flu and SARS. GTP's Vector Operations team now actively supports multiple critical IND and IND-enabling programs for which life-saving drug products are currently being developed and/or manufactured for use in phase I/II human clinical trials.

A new position of Manager of QC Cloning and Characterization in the Biochemical Group of the Analytical Sciences & Technology team is needed to support current operations. The QC Cloning Manager would report to Shujen Chen, Director of the Analytics Biochemical Group. The QC Cloning Manager is a critical position which will support the growing activities of GTPs analytics teams.

Responsibilities:
1. Interact with internal and external investigators, supervise direct reports to design and create strategies for cloning and construction of recombinant DNA for vector production.
2. Design and supervise direct reports to perform studies for trouble shooting issues related to AAV plasmid. Interpret sequencing results.
3. Lead the effort on maintaining database of plasmid DNA and AAV genome to ensure the integrity, accuracy and timely update of information.
4. Lead the effort on maintaining inventories, archives and working stocks of recombinant DNA
5. Develop novel assay for AAV plasmid quality control applying cutting edge techniques such as NGS or sec-MAL
6. Interact with Vector Core director closely to report and update research results and progress.
7. Train junior scientists at GTP and direct reports in the core on DNA construction and production.
8. Assist in lab management and enhancement of level of compliance with good laboratory practices in the Vector Core

Qualifications:

  • MS required with 5-7 years of relevant academic and pharmaceutical experience or an equivalent of education and experience required.
  • Expertise in cloning and construction of recombinant DNA.
  • Experience in maintaining a database of plasmid DNA and/or AAV genome.
  • Experience in training personnel in DNA construction, production, and troubleshooting.
  • Independent thinker with a track record of working collaboratively to achieve goals.
  • Highly functioning, detail-oriented, and analytical mind-set required.
  • Excellent oral/written communication and management skills required.


Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$59,703.00 - $113,435.00

Affirmative Action Statement
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements
Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.


To apply, visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/Translational-Research-Laboratories/Manager--QC-Cloning---Characterization_JR00026122





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Job No:
Posted: 11/11/2020
Application Due: 1/10/2021
Work Type:
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