The laboratory of Dr. Daniel Hollern at the Salk Institute of Biological Studies Department of Immunobiology and Microbial Pathogenesis in La Jolla, California seeks to recruit a Postdoctoral Fellow to engage in immuno-oncology research.

The main focus of the lab is to understand the immunological and molecular landscape of tumors with the goal of leveraging the immune component to promote anti-tumor immunity. In more detail, the lab is particularly interested in developing these approaches through the study of tumor infiltrating B cells and T cells. These studies will be pursued in syngeneic, orthotopic and genetically engineered mouse models as well as patient specimens.  The lab utilizes a multidisciplinary approach blending biologically appropriate models, molecular biology, and genomic analytical techniques including single cell and spatial transcriptomics and proteomics to interrogate pertinent questions in a number of in vitro and in vivo translational studies of breast cancer.

Position Highlights:

• Be involved in exciting projects to understand B cell and T cell immunobiology in solid cancers and studies exploring novel immunotherapeutic strategies.
• Conduct independent and collaborative studies in an Immunology lab focusing on clinically-relevant translational studies.
• Opportunity to learn techniques in single-cell and spatial computational genomics and immuno-oncology by projects investigating beneficial patient outcomes and anti-tumor immunity.
• Opportunity to develop new models for immune-oncology research.
• Participation at scientific meetings, membership in relevant scientific organizations, and applying for training grants will be encouraged and supported.

Ideal Candidate:

• Experience with analysis of genomic datasets such as RNA-seq, spatial datasets and single cell sequencing.
• Experience working with lab animals and expertise in the following cellular biology techniques:
• Murine syngeneic and genetically engineered models of cancers as well as allografts/xenografts
• Multi-parameter flow cytometry
• Cell culture
• Elispot or Luminex-based assays for cytokine/chemokine assessments.
• Immunofluorescent staining, imaging and fluorescent microscopy.
• Experience with standard molecular biology assays and genome editing (Crispr).
• Experience with proven record of publications in reputable journals, preferred.

Responsibilities:

• Perform investigational studies to understand the tumor microenvironment.
• Execute experiments independently and contribute to collaborative projects.
• Write grants.
• Write manuscripts for publishing.
• Train and supervise junior staff and participate in overall lab management.
• Analyze and present data at local and national meetings.

Credentials and Qualifications:

Ph.D. in Immunology, Cellular/Molecular Biology, or related fields. M.D. are welcome to apply. Hands-on-experience in laboratory research and good computer skills are required.