Professional Research Assistant

Job description


University of Colorado – School of Medicine 

Department of Surgery, Division of Urology

Professional Research Assistant

Position #00779153

The University of ColoradoDenver l Anschutz Medical Campus seeks individuals with demonstrated commitmentto creating an inclusive learning and working environment.  We value theability to engage effectively with students, faculty and staff of diversebackgrounds.

The University of Colorado Denver | Anschutz Medical Campus is a public research university serving more than 18,000 students. We award nearly 4,000 degrees each year, including more graduate and professional degrees than any other Colorado institution. With our solid academic reputation, award-winning faculty and renowned researchers, we offer more than 140 highly rated degree programs through 13 schools and colleges. The university receives over $400 million in research awards each year. In addition to the wide array of health-related programs and facilities offered at CU Anschutz in Aurora, Colo. a significant number of undergraduate and graduate degree programs are taught at CU Denver, our comprehensive campus in the heart of downtown Denver—one of America’s most vibrant urban centers. CU Denver is located steps from the Denver Center for Performing Arts and the LoDo District affording our students, faculty and staff access to a broad array of academic, professional, community, recreational and cultural outlets.


A national leader in health care and life sciences, CU Anschutz is the only comprehensive academic health sciences center in Colorado and the largest in the Rocky Mountain region. Located in Aurora, Colo., it is one of the newest education, research and patient care facilities in the world. With six schools and colleges, CU Anschutz trains the health sciences workforce of the future by blending education, research and clinical care all in one place. This strategic collaboration among diverse health care fields allows knowledge to travel directly from the research bench to the patient’s bedside. Read CU Anschutz Quick Facts here.


Overall Description of Responsibility or Nature of Work:

The incumbent will be part of the research team studying the mechanisms of neurogenic bladder dysfunction due to demyelination of the neural pathways innervating the lower urinary tract, as well as epigenetic changes in bladder sensory and spinal neurons. Research in the lab utilizes state-of-the-art technologies, including patch-clamp recordings in primary smooth muscle cell cultures and human cell lines, bladder innervating sensory and motor neurons, in vitro contractility studies, and pharmacogenetics in combination with in vivo urodynamic assessment of bladder function.

Specific Position Duties with Percentages of Time:

    Investigate molecular mechanisms of neurogenic bladder dysfunction due to demyelination in the central nervous system using a mouse model of coronavirus-induced multiple sclerosis.
    Learn a novel in vivo pharmacological approach using DREADDs for silencing bladder nociceptive neurons via AAV-driven delivery of hM4Di receptors Perform experiments involving nucleic acid and protein isolation, RT-PCR and qPCR, Western blotting, use of adenoviral vectors  Prepare data for presentations and publicationsAttend weekly lab meetings, and individual meetings with the mentorAdditional experiments will test the role of epigenetic changes in a number of nociception-related genes modulated by transcriptional complexes such as the Methyl-CpG-binding protein 2.
Salary and Benefits: Salary iscommensurate with skills and experience. The University of Colorado offers afull benefits package. Information on University benefits programs, includingeligibility, is located at Employee Services.

 University ofColorado Denver | Anschutz Medical Campus is dedicated to ensuring a safe andsecure environment for our faculty, staff, students and visitors. To assist inachieving that goal, we conduct background checks for all new employees priorto their employment.

 The ImmigrationReform and Control Act requires that verification of employment eligibility bedocumented for all new employees by the end of the third day of work. Alternativeformats of this ad are available upon request for persons with disabilities.

 Yourtotal compensation goes beyond the number on your paycheck. The University ofColorado provides generous leave, health plans and retirement contributionsthat add to your bottom line.

  Benefits: Calculator:

 Diversityand Equity:

 Pleaseclick here for information on disability accommodations: 

 The University of Colorado Denver | AnschutzMedical Campus is committed to recruiting and supporting a diverse studentbody, faculty and administrative staff. The university strives to promote aculture of inclusiveness, respect, communication and understanding. Weencourage applications from women, ethnic minorities, persons with disabilitiesand all veterans. The University of Colorado is committed to diversity andequality in education and employment.

QualificationsMinimum Requirements:

  • BA or BSc with at least 1 year of laboratory research experience
Applicants must meet minimum qualifications at the time of hire.

Preferred Qualifications:

  • At least 2 years of laboratory research experience
  • Experience in mutagenesis; tissue-specific transgenic vectors; qRT-PCR, Western Blot; in vivo Co-immunoprecipitation; Confocal microscopy, FACS, cell culture, transfections; generation of KO mice, genotyping.
  • Co-authored publications in peer-reviewed biomedical journals
  • Experience with optogenetic approaches, and in vivo electrophysiology

Job Category: Faculty
Primary Location: Aurora
Schedule: Full-time
Posting Date: Oct 16, 2020
Unposting Date: Ongoing




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Job No:
Posted: 10/17/2020
Application Due: 1/15/2021
Work Type: