Research Assistant 2

Job description

Job Title: Research Assistant 2
Location: Case Main Campus
Regular/Temporary: Regular
Full/Part Time: Full-Time
Job ID: 8493

Working with independence and under general direction, the research assistant will plan and carry out research assignments of a routine and non-routine nature that will utilize established, new and innovative research techniques. The lab studies human malaria parasites, parasitic worms and recently SARS-CoV-2. This position will primarily involve research on malaria parasites and SARS-CoV-2. The malaria research projects are to understand the molecular interaction of how malaria parasites invade human erythrocytes with the aim to develop effective malaria vaccines therapeutic monoclonal antibodies. The studies on SARS-CoV-2 intend to determine the factors that regulate the type antibody responses infected individuals develop to the virus, how long these antibodies persist, and whether they are associated with protection from re-infection or disease.


    Research activities focusing on development of assays for characterizing of functional antibodies against malaria parasite antigens and for SARS-CoV-2. May assist in developing improved techniques, projection methods or procedures. (47%)Clone and sequence genes. Perform genetic manipulation of human, malaria and SARS-CoV-2 genes such as site directed mutagenesis, gene knockouts, and design gene synthesis, and to construct human monoclonal antibodies. (20%)Collect, analyze and integrate data into overall experimental objectives. Evaluate the adequacy of techniques; study and test new procedures. (10%)


    Express proteins, construct expression vectors, perform cell culture. (5%)Perform the following: Design PCR and multiplex assays, flow cytometry, enzyme-linked immunoassays and Surface plasmon resonance. (5%)Supervise students in bench skills, and contributions to large-scale research projects. (5%)Present research findings and other current research on related topics at regular group. (5%)Oversee inventory. Stock and maintain laboratory inventory, familiarize with the available literature. Perform other duties as assigned. (3%)


Department: Daily contact with supervisor to discuss updates, results, ideas, and questions. The RA2 will contribute to a much larger and highly technical research project, as part of a collaborative effort. Continual communication and guidance are expected.

University: Weekly contact with other departments. Weekly lectures with other departments are an important way of staying connected and aware of current research.

External: Daily or weekly contact with vendors. Vendors frequently come through the labs to promote their businesses and products.

Students: Daily contact with student employees and volunteers. Although our lab does not currently have any new students, if we do recruit any, this position would assist in mentoring the students.


Training and supervision of new students.


Education/Experience: Bachelor of science degree and 1 to 3 years of experience in molecular biology or Associate's degree in an approved biotechnology program and 2 to 4 years of experience in molecular biology.


    Must be hard-working, flexible, quick thinking, organized, communicative, able to multitask, able to learn the research, take initiative, work with many different people from different countries and backgrounds, able to keep up with a demanding, but positive and interactive work environment. Has knowledge of commonly-used concepts, practices, and procedures within molecular biology, biochemistry, and immunology or be able to derive information from background reading and lab meetings and learn quickly. Prefer some background in malaria parasite culture, tissue culture, and ELISA assays. Relies on instructions, pre-established guidelines, and protocols to perform the functions of the job. If a protocol is not provided, a person must be able to research, understand, and troubleshoot protocols with some degree of independence. Ability to operate laboratory equipment. Experience in data analysis and navigating various analysis software systems is a plus. Communicate effectively. Ability to interact with colleagues, supervisors, and customers face to face. Ability to meet consistent attendance. Work under pressure and remain flexible.


The laboratory environment is categorized biosafety level 2. We work with malaria, E.coli, and SARS-CoV-2, human cell culture. We only use samples from Covid-19 patients that have been appropriately inactivated if the samples were collected from individuals presenting with acute disease; only then can the samples be used in our laboratory. Formaldehyde is kept and used infrequently. We have an appointed safety officer who trains all lab members on all necessary information and precautions. Additionally, there is a mandatory training in lab safety and blood borne pathogens issued by Case Western Reserve.

Diversity Statement

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.


Reasonable Accommodations

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.





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Job No:
Posted: 10/7/2020
Application Due: 1/5/2021
Work Type: