School of Medicine:
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Comprised of 2,400 faculty physicians and researchers, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System create Duke Health. Duke Health is a world-class health care network. Founded in 1998 to provide efficient, responsive care, the health system offers a full network of health services and encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Primary Care, Private Diagnostic Clinic, Duke Home and Hospice, Duke Health and Wellness, and multiple affiliations.
Research Topi c: Immune development in infants andchildren
Our lab studies the factors involved inimmune respon ses to vaccines in infants and children with primary and secondaryimmune deficiency disorders. Specific groups included in these studies areinfa nts born to HIV-infected mothers, children who received immune suppressi ontherapy, and children with genetic disorders that affect immune develo pment. Scientificapproaches include the Application of deep sequencing t o define the bloodglobal transcriptome across key study populations, use of flow cytometry todefine lymphocyte and monocyte subpopulations, and measurement of plasmabiomarkers that are involved in immune development. Most of the effort (0.7FTE) for this position will come from 1R21HD1028 53-01 Impact of maternal HIV infection on immunepriming of their uninfected infants with additional funding f rom the Division ofPediatric Genetics. There is a need toc haracterize the immune response to ERT in Pompe disease beyond the curre ntunderstanding of IgG response to the therapeutic protein. Deep immune phenotypingand proteomics data interpretation are needed. In addition it is important tounderstand the immune dysregulation at baseline due to b urden of disease evenprior to ERT initiation. Other studies involved in this position relate to the understandingof the possible role of immunit y in Down syndrome disintegrative disorder.
Requirements:< p>- Previousflow cytometry
-Knowledgeof interpretation RNA gene e xpression
-Measurementsof plasma based biomarkers
-Performa variety of molecular, cellular, biochemical a nd immunological analyses.
-Design,execute and docume nt experiments with sufficient detail to understand andrepeat by other l ab members.
-Compileand document results, maintain la b notes, and assist in writing reports andresearch manuscripts. p>
See job description for education requirements.
See job description for requirements.
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